Journal Articles
Mastana, S, Halai, KC, Akam, L, Hunter, D, Singh, P (2024)
Genetic Polymorphisms and Genetic Risk Scores Contribute to the Risk of Coronary Artery Disease (CAD) in a North Indian Population,
International Journal of Molecular Sciences, 25(15), pp.8552-8552, ISSN: 1661-6596. DOI:
10.3390/ijms25158552.
Anastasiou, K, Morris, M, Akam, L, Mastana, S (2024)
The Genetic Profile of Combat Sport Athletes: A Systematic Review of Physiological, Psychological and Injury Risk Determinants,
International Journal of Environmental Research and Public Health, 21(8), pp.1019-1019, ISSN: 1661-7827. DOI:
10.3390/ijerph21081019.
Mastana, S, Knight, E, Hampson, A, Akam, L, Hunter, D, Ghelani, A, Samanta, A, Singh, P (2024)
Role of Selected Genetic Polymorphisms in the Development of Rheumatoid Arthritis in a British White Population,
Genes, 15(8), pp.1009-1009, DOI:
10.3390/genes15081009.
Doody, NE, Smith, NJ,
Akam, EC, Askew, GN, Kwok, JCF, Ichiyama, RM (2024)
Differential expression of genes in the RhoA/ROCK pathway in the hippocampus and cortex following intermittent hypoxia and high-intensity interval training,
Journal of Neurophysiology, 132(2), pp.531-543, ISSN: 0022-3077. DOI:
10.1152/jn.00422.2023.
Brown, M-J, Akam, L, Nickels, M, Morris, M (2024)
Publisher Correction: The protective effect of endurance running against the pro-invasive effects of ageing in breast cancer cells and mesenchymal stem cells in vitro,
In vitro models, 3(2-3), pp.151-156, DOI:
10.1007/s44164-024-00069-0.
Hayward, E, Akam, L, Hunter, D, Mastana, S (2024)
Role of the menstrual cycle on performance and injury risk: a survey of female professional rugby players in the United Kingdom,
International Journal of Environmental Research and Public Health, 21(2), 150, DOI:
10.3390/ijerph21020150.
Brown, M, Nickels, M, Akam, L, Morris, M (2023)
The protective effect of endurance running against the pro-invasive effects of ageing in breast cancer cells and mesenchymal stem cells in vitro,
In vitro models, 2(6), pp.263-280, DOI:
10.1007/s44164-023-00055-y.
Craig, J, Akam, L, Bailey, S, Ferguson, R, ODonnell, E (2023)
Calf blood flow is augmented in habitually aerobically trained versus untrained postmenopausal women in association with favorable modulation of vasculo‐metabolic interactions,
Scandinavian Journal of Medicine & Science in Sports, 33(6), pp.882-893, ISSN: 0905-7188. DOI:
10.1111/sms.14335.
Shitomi-Jones, LM, Akam, L, Hunter, D, Singh, P, Mastana, S (2023)
Genetic risk scores for the determination of type 2 diabetes mellitus (T2DM) in North India,
International Journal of Environmental Research and Public Health, 20(4), 3729, DOI:
10.3390/ijerph20043729.
Brown, M-J, Morris, M, Akam, L (2023)
Investigating the effects of indirect coculture of human mesenchymal stem cells on the migration of breast cancer cells: a systematic review and meta-analysis,
Breast Cancer: Basic and Clinical Research, 17, pp.1-13, ISSN: 1178-2234. DOI:
10.1177/11782234221145385.
Bahsoun, S, Brown, M-J, Coopman, K,
Akam, EC (2022)
Cryopreservation of human bone marrow derived mesenchymal stem cells at high concentration is feasible,
Biopreservation and Biobanking, 21(5), pp.450-457, ISSN: 1947-5535. DOI:
10.1089/bio.2022.0017.
Mok, J, Brown, M-J, Akam, L, Morris, M (2022)
The lasting effects of resistance and endurance exercise interventions on breast cancer patient mental wellbeing and physical fitness,
Scientific Reports, 12, 3504, DOI:
10.1038/s41598-022-07446-3.
Nickels, M, Mastana, S, Denniff, M, Codd, V, Akam, L (2022)
Pilates and telomere dynamics: A 12-month longitudinal study,
Journal of Bodywork and Movement Therapies, 30(2022), pp.118-124, ISSN: 1360-8592. DOI:
10.1016/j.jbmt.2022.02.013.
Nickels, M, Mastana, S, Codd, V, Denniff, M, Akam, L (2021)
Comparison of telomere length in young and master endurance runners and sprinters,
Journal of Aging and Physical Activity, 30(3), pp.510-516, ISSN: 1063-8652. DOI:
10.1123/japa.2021-0236.
Brown, M-J, Morris, M, Akam, L (2020)
An exploration of the role of exercise in modulating breast cancer progression in vitro: a systematic review and meta-analysis,
American Journal of Physiology-Cell Physiology, 320(3), ISSN: 0363-6143. DOI:
10.1152/ajpcell.00461.2020.
Bahsoun, S, Coopman, K, Akam, L (2020)
Quantitative assessment of the impact of cryopreservation on human bone marrow-derived mesenchymal stem cells: up to 24 h post-thaw and beyond,
Stem Cell Research and Therapy, 11, 540, ISSN: 1757-6512. DOI:
10.1186/s13287-020-02054-2.
Nickels, M, Mastana, S, Denniff, M, Codd, V, Akam, L (2020)
Elite swimmers possess shorter telomeres than recreationally active controls,
Gene, 769, 145242, ISSN: 0378-1119. DOI:
10.1016/j.gene.2020.145242.
Nickels, M, Mastana, S, Hunter, D, Denniff, M, Codd, V, Akam, L (2020)
The effect of a 12-week resistance training intervention on leukocyte telomere length,
Heliyon, 6(6), e04151, ISSN: 2405-8440. DOI:
10.1016/j.heliyon.2020.e04151.
Turner, M, Martin, N, Player, DJ, Ferguson, R, Wheeler, P, Green, CJZ, Akam, L, Lewis, M (2020)
Characterising hyperinsulinaemia induced insulin resistance in human skeletal muscle cells,
Journal of Molecular Endocrinology, 64(3), pp.125-132, ISSN: 0952-5041. DOI:
10.1530/jme-19-0169.
Akam, L, Tansey, S, Hastings, B (2019)
The effect of low-resistance high-repetition resistance training on longer-term functional adaptations and total athletic score,
Archives of Physical Health and Sports Medicine, 2(2), pp.8-15, ISSN: 2639-1805.
Bahsoun, S, Coopman, K, Akam, L (2019)
The impact of cryopreservation on bone marrow-derived mesenchymal stem cells: a systematic review,
Journal of Translational Medicine, 17(1), 397, DOI:
10.1186/s12967-019-02136-7.
Brown, M-J, Bahsoun, S, Morris, M, Akam, L (2019)
Determining conditions for successful culture of multi-cellular 3D tumour spheroids to investigate the effect of mesenchymal stem cells on breast cancer cell invasiveness,
Bioengineering, 6(4), 101, ISSN: 2306-5354. DOI:
10.3390/bioengineering6040101.
Kow, M, Akam, L, Singh, P, Singh, M, Cox, N, Bhatti, JS, Tuck, SP, Francis, RM, Datta, H, Mastana, S (2019)
Vitamin D receptor (VDR) gene polymorphism and osteoporosis risk in White British men,
Annals of Human Biology, 46(5), pp.430-433, ISSN: 0301-4460. DOI:
10.1080/03014460.2019.1659851.
Akam, L and Riley-Smith, K (2019)
Pilates conventional or complementary?,
Advances in Complementary & Alternative Medicine, 4(4), ACAM.000596.2019, ISSN: 2637-7802. DOI:
10.31031/ACAM.2019.04.000596.
Bahsoun, S, Coopman, K, Forsyth, NR, Akam, L (2019)
The role of dissolved oxygen levels on human Mesenchymal Stem Cell culture success, regulatory compliance and therapeutic potential,
Stem Cells and Development, ISSN: 1547-3287. DOI:
10.1089/scd.2017.0291.
Butler, SJ, Young, A, Akam, L, Sinha, N, Agrawal, S, Mastana, S (2018)
Association of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms with coronary artery disease (CAD) in a North Indian population,
Cogent Medicine, 5, ISSN: 2331-205X. DOI:
10.1080/2331205X.2018.1478477.
McMullan, C, Dowejko, M, Cox, N, Ghelani, AM, Akam, L, Samanta, A, Mastana, S (2018)
Genetic analysis of common variants of MMPs and their involvement in Rheumatoid Arthritis in the East Midlands, UK,
Journal of Clinical Genomics, 1(1), pp.1-4.
Turner, M, Player, DJ, Martin, N, Akam, L, Lewis, M (2018)
The effect of chronic high insulin exposure upon metabolic and myogenic markers in C2C12 skeletal muscle cells and myotubes,
Journal of Cellular Biochemistry, ISSN: 0730-2312. DOI:
10.1002/jcb.26748.
Doody, N, Dowejko, M, Akam, L, Cox, N, Bhatti, JS, Singh, P, Mastana, S (2017)
The role of TLR4, TNF-α and IL-1β in type 2 diabetes mellitus development within a North Indian Population,
Annals of Human Genetics, 81, pp.141-146, ISSN: 1469-1809. DOI:
10.1111/ahg.12197.
Mastana, S, Prakash, S, Akam, L, Kirby, M, Lindley, M, Sinha, N, Agrawal, S (2017)
Genetic association of pro-inflammatory cytokine gene polymorphisms with coronary artery disease (CAD) in a North Indian population,
Gene, ISSN: 0378-1119. DOI:
10.1016/j.gene.2017.07.050.
Laybourn, S, Akam, L, Cox, N, Singh, P, Mastana, S (2016)
Genetic analysis of novel Alu insertion polymorphisms in selected Indian populations,
American journal of human biology : the official journal of the Human Biology Council, ISSN: 1042-0533. DOI:
10.1002/ajhb.22881.
Choudhury, S, Akam, L, Mastana, S (2014)
Genetic analysis of CYP2D6 polymorphism in Indian populations and its pharmacogenetic implications,
Current Pharmacogenomics and Personalized Medicine, 12(2), pp.123-132, ISSN: 1875-6921. DOI:
10.2174/1875692112666140908231649.
Schmidt, JA, Bell, FM,
Akam, E, Marshall, C, Dainty, IA, Heinemann, A, Dougall, IG, Bonnert, RV, Sargent, CA (2013)
Biochemical and pharmacological characterization of AZD1981, an orally available selective DP2 antagonist in clinical development for asthma,
British Journal of Pharmacology, 168(7), pp.1626-1638, ISSN: 0007-1188. DOI:
10.1111/bph.12053.
Luker, T, Bonnert, R, Schmidt, J, Sargent, C, Paine, SW, Thom, S, Pairaudeau, G, Patel, A, Mohammed, R,
Akam, E, Dougall, I, Davis, AM, Abbott, P, Brough, S, Millichip, I, McInally, T (2011)
Switching between agonists and antagonists at CRTh2 in a series of highly potent and selective biaryl phenoxyacetic acids,
Bioorganic & Medicinal Chemistry Letters, 21(12), pp.3616-3621, ISSN: 0960-894X. DOI:
10.1016/j.bmcl.2011.04.101.
Akam, E and Strange, PG (2004)
Inverse agonist properties of atypical antipsychotic drugs,
Biochemical Pharmacology, 67(11), pp.2039-2045, ISSN: 0006-2952. DOI:
10.1016/j.bcp.2004.02.017.
Akam, EC, Challiss, RAJ, Nahorski, SR (2001)
G(q/11) and G(i/o) activation profiles in CHO cells expressing human muscarinic acetylcholine receptors: dependence on agonist as well as receptor-subtype,
BRITISH JOURNAL OF PHARMACOLOGY, 132(4), pp.950-958, ISSN: 0007-1188. DOI:
10.1038/sj.bjp.0703892.
Akam, EC, Nahorski, SR, Challiss, RAJ (1998)
Analysis of M-1, M-2, M-3, M-4-muscarinic cholinoceptor-G protein coupling using [S-35]-GTP gamma S and G alpha-specific immunoprecipitation,
BRITISH JOURNAL OF PHARMACOLOGY, 125, ISSN: 0007-1188.
Akam, EC, Challiss, RAJ, Nahorski, SR (1998)
Methacholine-stimulated [S-35]-GTP gamma S binding and Ca2+ mobilisation in CHO-cells expressing M-1 and M-3 cholinoceptors,
BRITISH JOURNAL OF PHARMACOLOGY, 123, pp.U91-U91, ISSN: 0007-1188.
Akam, EC, Carruthers, AM, Nahorski, SR, Challiss, RAJ (1997)
Pharmacological characterization of type 1 alpha metabotropic glutamate receptor-stimulated [S-35]-GTP gamma S binding,
BRITISH JOURNAL OF PHARMACOLOGY, 121(6), pp.1203-1209, ISSN: 0007-1188. DOI:
10.1038/sj.bjp.0701238.
Akam, EC, Challiss, RAJ, Nahorski, SR (1996)
Inverse agonist activity of atropine at human M(2) and M(4) muscarinic acetylcholine receptors revealed by [S-35]-GTP gamma S binding,
BRITISH JOURNAL OF PHARMACOLOGY, 119, pp.P6-P6, ISSN: 0007-1188.
Akam, EC, Carruthers, AM, Nahorski, SR, Challiss, RAJ (1996)
Use of [S-35]-GTP gamma S binding to assess type 1 alpha metabotropic glutamate receptor activity in baby hamster kidney cell membranes,
BRITISH JOURNAL OF PHARMACOLOGY, 119, pp.P231-P231, ISSN: 0007-1188.
Sommers, L, Akam, L, Hunter, DJ, Bhatti, JS, Mastana, S (Accepted for publication) Role of the ACE I/D Polymorphism in Selected Public Health-Associated Sporting Modalities: An Updated Systematic Review and Meta-Analysis, International Journal of Environmental Research and Public Health, 21(11), pp.1439-1439, DOI: 10.3390/ijerph21111439.
