Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Research Publications


Publications for Gareth Pritchard

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Journal Articles

Wang, Y, Pritchard, G, Kimber, M (2020) A general convergent strategy for the synthesis of tetra-substituted furan fatty acids (FuFAs), European Journal of Organic Chemistry, 2020(19), pp.2914-2922, ISSN: 1434-193X. DOI: 10.1002/ejoc.202000234.

Wang, Y, Pritchard, G, Kimber, M (2019) Total synthesis of the tetrasubstituted furan fatty acid metabolite CeDFP via Au-catalyzed intermolecular alkyne hydroarylation, Organic Letters, 21(12), pp.4892-4895, ISSN: 1523-7060. DOI: 10.1021/acs.orglett.9b01786.

Capel, NJ, Lindley, M, Pritchard, G, Kimber, M (2019) Indium-mediated 2-oxonia cope rearrangement of 1,4-dienols to 1,3-dienols, ACS Omega, 4(1), pp.785-792, DOI: 10.1021/acsomega.8b03118.

Baker, L, Martin, N, Kimber, M, Pritchard, G, Lindley, M, Lewis, M (2018) Resolvin E1 (RvE1) attenuates LPS induced inflammation and subsequent atrophy in C2C12 myotubes, Journal of Cellular Biochemistry, ISSN: 0730-2312. DOI: 10.1002/jcb.26807.

Lee, R, Lindley, M, Pritchard, G, Kimber, M (2017) A biosynthetically inspired route to substituted furans using the Appel reaction: total synthesis of the furan fatty acid F5, Chemical Communications, 53(47), pp.6327-6330, ISSN: 0009-241X. DOI: 10.1039/C7CC03229C.

Ahmed, A, Christie, S, Pritchard, G (2017) A comparison of the benzylic and the allylic group as a donor in the formal [4+2] cycloaddition to tetrahydropyrans using donor-acceptor cyclobutanes, Tetrahedron Letters, ISSN: 0040-4039. DOI: 10.1016/j.tetlet.2017.06.046.

D.-R, BF, Elsegood, M, Fairley, G, Pritchard, G, Weaver, G (2016) Pyridone functionalization: regioselective deprotonation of 6-methylpyridin-2(1H)- and -4(1H)-one derivatives, European Journal of Organic Chemistry, ISSN: 1434-193X. DOI: 10.1002/ejoc.201601156.

Fernandez-Diaz-Ropero, B, Elsegood, M, Fairley, G, Pritchard, G, Teat, SJ, Weaver, G (2015) Isolation and structure determination of the first example of the azeto[2,3-c]quinolizinedione ring system, Tetrahedron Letters, ISSN: 1873-3581. DOI: 10.1016/j.tetlet.2015.07.029.

Ahmed, A, Christie, SDR, Elsegood, MRJ, Pritchard, GJ (2013) A mild Lewis acid mediated epoxy-ester to bicyclic ortho ester rearrangement, Chemical Communications, 49(68), pp.7489-7491, ISSN: 1359-7345. DOI: 10.1039/c3cc44364g.

Bowman, WR, Lyon, JE, Pritchard, GJ (2012) Palladium and radical routes to phenanthridines, Arkivoc, 2012(7), pp.210-227, ISSN: 1551-7012. DOI: 10.3998/ark.5550190.0013.714.

Allart, EA, Christie, S, Pritchard, GJ, Elsegood, MRJ (2009) Preparation of Highly Substituted Tetrahydropyrans via a Metal Assisted Dipolar Cycloaddition Reaction, Chemical Communications, pp.7339-7341.

Bowman, WR, Lyon, JE, Pritchard, GJ (2008) Palladium-Mediated Synthesis of Phenanthridines: The First Report of Palladium Insertion into Imidoyl Selenides, Synlett, (14), pp.2169-2171.

Singh, S, Williams, SA, Shah, MH, Lectka, T, Pritchard, GJ, Issacs, JT, Denmeade, SR (2008) Mechanistic Insights into the Inhibition of Prostate Specifici Antigen by β-lactam Class Compounds, Proteins: Structure, Function and Bioinformatics, 70, pp.1416-1428, ISSN: 0887-3585.

Paddon, CA, Atobe, M, Fuchigami, T, He, P, Watts, P, Haswell, SJ, Pritchard, GJ, Bull, SD, Marken, F (2006) Towards paired and coupled electrode reactions for clean organic microreactor electrosyntheses, Journal of Applied Electrochemistry, 36, pp.617-634.

Irlapati, NR, Baldwin, JE, Adlington, RM, Pritchard, GJ, Cowley, AR (2006) Studies towards the biomimetic synthesis of pyridomacrolidin, Tetrahedron, 62, pp.4603-4614.

Irlapati, NR, Baldwin, JE, Adlington, RM, Pritchard, GJ, Cowley, AR (2005) Regio- and stereospecific [3+2] cycloaddition of an unusual nitrone derived from a N-hydroxy-2-pyridone with medium ring enones, Tetrahedron, 61, pp.1773-1784.

Irlapati, NR, Adlington, RM, Conte, A, Pritchard, GJ, Marquez, R, Baldwin, JE (2004) Total synthesis of pyridovericin, Tetrahedron, 60, pp.9307-9317.

Christie, S, Davoile, RJ, Elsegood, MRJ, Fryatt, R, Jones, RCF, Pritchard, GJ (2004) Novel formation and use of a Nicholas carbocation in the synthesis of highly substituted tetrahydrofurans, Chemical Communications, 2004(21), pp.2474-2475, ISSN: 1359-7345. DOI: 10.1039/b411367e.

Irlapati, NR, Baldwin, JE, Adlington, RM, Pritchard, GJ, Cowley, A (2003) An Unusual Oxidative Cyclisation: Studies towards the Biomimetic Synthesis of Pyridomacrolidin, Organic Letters, 5, pp.2351-2354.

Adlington, RM, Baldwin, JE, Mayweg, AVW, Pritchard, GJ (2003) Expedient synthesis of a highly substituted troplone via a 3-oxidopyrylium [5+2] cycloaddition reaction, Tetrahedron Letters, 44, pp.4543-4545.

Adamo, MFA, Adlington, RM, Baldwin, JE, Pritchard, GJ, Rathmell, RE (2003) Practical routes to diacetylenic ketones and their application for the preparation alkynyl substituted pyridines, pyrimidines and pyrazoles, Tetrahedron, 59, pp.2197-2205.

Marken, F, Paddon, CA, Pritchard, GJ, Thiemann, T (2002) Paired electrosynthesis : micro-flow cell processes with and without added electrolyte, Electrochemistry Communications, 4(10), pp.825-831, ISSN: 1388-2481. DOI: 10.1016/S1388-2481(02)00462-9.

Gygi, CM, Leibovitch, IY, Adlington, RM, Baldwin, JE, Chen, BN, McCoull, W, Pritchard, GJ, Becker, GW, Dixon, EP, Little, SP, Sutkowski, DM, Teater, C, Neubauer, BL (2002) Prostate-Specific Antigen (PSA)-mediated Proliferation, Androgenic Regulation and Inhibitory Effects of LY312340 in HOS-TE85 (TE85) Human Osteosarcoma Cells, ANTICANCER RESEARCH, 22, pp.2725-2732, ISSN: 0250-7005.

Adlington, RM, Baldwin, JE, Mayweg, AVW, Pritchard, GJ (2002) Biomimetic Cycloaddition Approach to Tropolone Natrual Products via a Tropolone Ortho-quinonie Methide, Organic Letters, 4, pp.3009-3011.

Baldwin, JE, Adlington, RM, Conte, A, Irlapati, NR, Marquez, R, Pritchard, GJ (2002) Total Synthesis of Pyridovericin: Studies toward the Biomimetic Synthesis of Pyridomacrolidin, Organic Letters, 4(13), pp.2125-2127, ISSN: 1523-7060. DOI: 10.1021/ol0200504.

Adlington, RM, Baldwin, JE, Cox, RJ, Pritchard, GJ (2002) A Rapid Entry to Natural and Unnatural Disubstituted Maleic Anhydrides, Synlett, pp.820-822.

Baldwin, JE, Adlington, RM, Conte, A, Irlapati, NR, Marquez, R, Pritchard, GJ (2002) Total synthesis of pyridovericin: Studies toward the biomimetic synthesis of pyridomacrolidin, Organic Letters, 4(13), pp.2125-2127.

Baldwin, JE, Pritchard, GJ, Rathmell, RE (2001) The reactions of diacetylenic ketones with nitrogen nucleophiles; faclie preparation of alkynyl substituted pyrimidines and pyrazoles, Journal of the Chemical Society, Perkin Transactions 1, pp.2906-2908.

Baldwin, JE, Pritchard, GJ, Williamson, DS (2001) Synthesis of 4-arylsulfonyl-substituted kainoid analogues from -4-hydroxy-L-proline, Tetrahedron, 57, pp.7991-7997.

Adlington, RM, Baldwin, JE, Becker, GW, Chen, B, Cheng, L, Cooper, SL, Hermann, RB, Howe, TJ, McCoull, W, McNulty, AM, Neubauer, BL, Pritchard, GJ (2001) Design, Synthesis, and Proposed Active Site Binding Analysis of Monocyclic 2-Azetidinone Inhibitors of Prostate Specific Antigen, Journal of Medicinal Chemistry, 44(10), pp.1491-1508, ISSN: 0022-2623. DOI: 10.1021/jm000145g.

Baldwin, JE, Fryer, AM, Pritchard, GJ (2001) Parallel Synthesis of Novel Heteroaromatic Acromelic Acid Analogues from Kainic Acid, Journal of Organic Chemistry, 66(8), pp.2588-2596.

Baldwin, JE, Fryer, AM, Pritchard, GJ (2001) ¹H NMR Study of Protected and Unprotected Kainoid Amino Acids: Facile Assignment of C-4 Stereochemistry, Journal of Organic Chemistry, 66, pp.2597-2601.

Baldwin, JE, Fryer, AM, Pritchard, GJ (2001) 1H NMR study of protected and unprotected kainoid amino acids: Facile assignment of C-4 stereochemistry, Journal of Organic Chemistry, 66(8), pp.2597-2601, ISSN: 0022-3263. DOI: 10.1021/jo000847d.

Adlington, RM, Baldwin, JE, Catterick, D, Pritchard, GJ (2001) The efficient, enantioselective synthesis of quinoxaline, pyrazine and 1,2,4-triazine substituted α-amino acids from vicinal tricarbonyls, Journal of the Chemical Society, Perkin Transactions 1, pp.668-679.

(2000) Synthesis of Novel Unsymmetrical and Symmetrical Diacetylenic Ketones, Synthetic Communications, 30(21), pp.3833-3847, ISSN: 0039-7911. DOI: 10.1080/00397910008086940.

Baldwin, JE, Pritchard, GJ, Williamson, DS (2000) The Synthesis of 4-Arylsulfanyl-substituted Kainoid Analogues from trans-4-Hydroxy-l-proline, Bioorganic & Medicinal Chemistry Letters, 10(17), pp.1927-1929, ISSN: 0960-894X. DOI: 10.1016/s0960-894x(00)00352-8.

Baldwin, JE, Adlington, RM, Challis, GL, Cox, RJ, Pritchard, GJ (2000) Towards a Biomimetic Synthesis of the Marine Alkaloids Papuamine and Haliclonadiamine: Model Studies, Tetrahedron, 56(4), pp.623-628, ISSN: 0040-4020.

Baldwin, JE, Adlington, RM, Pritchard, GJ, Spencer, KC (2000) Synthesis of novel -nucleosides with potential applications in combinatorial and parallel synthesis, Tetrahedron Letters, 41(4), pp.575-578.

Adlington, RM, Baldwin, JE, Catterick, D, Pritchard, GJ (2000) A versatile synthetic route to quinoxaline, pyrazine and 1,2,4-triazine substituted α-amino acids from vicinal tricarbonyls, Journal of the Chemical Society, Perkin Transactions 1, (3), pp.299-302, ISSN: 1470-4358.

Adlington, RM, Baldwin, JE, Catterick, D, Pritchard, GJ, Tang, LT (2000) The Synthesis of Novel Heterocyclic Substituted α-amino Acids: Further Exploitation of α-amino Acids Alkynyl Ketones, Journal of the Chemical Society, Perkin Transactions 1, (3), pp.303-305.

Baldwin, JE, Fryer, AM, Pritchard, GJ (2000) Novel C-4 Heteroaromatic Kainoid Analogues: a Parallel Synthesis Approach, Bioorganic and Medicinal Chemistry Letters, 10, pp.309-311.

Adlington, RM, Baldwin, JE, Catterick, D, Pritchard, GJ, Tang, LT (2000) The Synthesis of Novel Heterocyclic Substituted -Amino Acids: Further Exploitation of Alkynyl Ketones Reactive Substrates, Journal of the Chemical Society, Perkin Transactions 1, pp.2311-2316.

Baldwin, JE, Pritchard, GJ, Williamson, DS (2000) Synthesis of 4-arylsufonyl-substituted Kainoid Analogues from Trans-4-hydroxy-L-proline, Bioorganic and Medicinal Chemistry Letters, 10(17), pp.1927-1929.

Baldwin, JE, Pritchard, GJ, Rathmell, RE (2000) Synthesis of Novel Unsymmetrical and Symmetrical Diacetylenic Ketones, Synthetic Communications, 30(21), pp.3833-3847.

Adlington, RM, Baldwin, JE, Pritchard, GJ, Spencer, KC (2000) Synthesis of novel C-nucleosides with potential applications in combinatorial and parallel synthesis, Tetrahedron Letters, 41(4), pp.575-578, ISSN: 0040-4039. DOI: 10.1016/s0040-4039(99)02078-x.

Adlington, RM, Baldwin, JE, Challis, GL, Cox, RJ, Pritchard, GJ (2000) Towards a Biomimetic Synthesis of the Marine Alkaloids Papuamine and Haliclonadiamine: Model Studies, Tetrahedron, 56(4), pp.623-628, ISSN: 0040-4020. DOI: 10.1016/s0040-4020(99)01011-x.

Baldwin, JE, Mayweg, AVW, Neumann, K, Pritchard, GJ (1999) Studies toward the Biomimetic Synthesis of Tropolone Natural Products via a Hetero Diels−Alder Reaction, Organic Letters, 1(12), pp.1933-1935, ISSN: 1523-7060. DOI: 10.1021/ol991067y.

Adlington, RM, Baldwin, JE, Catterick, D, Pritchard, GJ (1999) The Synthesis of Pyrimidin-4-yl Substituted α-amino Acids, a Versatile Approach from Alkynyl Ketones, Journal of the Chemical Society, Perkin Transactions 1, pp.855-866.

Baldwin, JE, Beyeler, A, Cox, RJ, Pritchard, GJ, Adlington, RM, Watkins, DJ (1999) Reinvestigation of the Dimerisation Process Forming Isoglaucanic Acid, Tetrahedron, 55, pp.7363-7374.

Baldwin, JE, Maywegg, AVW, Neumann, K, Pritchard, GJ (1999) Studies Towards the Biomimetic Synthesis of Tropolone Natural Products via a Hetero Diels-Alder Reaction, Organic Letters, 1(12), pp.1933-1935.

Adlington, RM, Baldwin, JE, Pritchard, GJ, Williams, AJ, Watins, DJ (1999) A Biomimetic Synthesis of Lucidene, Organic Letters, 1(12), pp.1937-1939.

Wilmouth, RC, Kassamally, S, Westwood, NJ, Shepperd, RJ, Claridge, TDW, Wright, PA, Pritchard, GJ, Schofield, CJ (1999) Mechanistic Insights into the Inhibition of Serine Proteases by Monocyclic Lactams, Biochemistry, 38, pp.7989-7998.

Smith, K, El Hiti, GA, Pritchard, GJ, Hamilton, A (1999) Carbonylation of Various Organolithium Reagents. A Novel Approach to Heterocycles Intramolecular Trapping of Aromatic Acyllithiums, Journal of the Chemical Society, Perkin Transactions 1, pp.2299-2303.

Adlington, RM, Baldwin, JE, Catterick, D, Pritchard, GJ (1998) A Versatile Approach to Pyrimidin-4-yl Substituted α-amino Acids from Alkynyl Ketones; the Total Synthesis of L-Lathyrine, Journal of the Chemical Society, Chemical Communications, pp.1757-1758.

Adlington, RM, Baldwin, JE, McCoull, W, Pritchard, GJ, Schofield, CJ, Westwood, NJ (1998) An Investigation of the -arylsulfonylation of 2-azetidinones, Synthetic Communications, 27, pp.3803-3813.

Baldwin, JE, Fryer, AM, Pritchard, GJ, Spyvee, MR, Whitehead, RC, Wood, ME (1998) Concise Syntheses of Acromelic Acid A and -Acromelic Acid A, Tetrahedron Letters, 39, pp.707-710.

Baldwin, JE, Fryer, AM, Pritchard, GJ, Spyvee, MR, Whitehead, RC, Wood, ME (1998) A Biomimetic Approach to the Pyridone Rings of the Acromelic Acids: A Concise Synthesis of Acromelic Acid A and an Approach to Acromelic Acid B, Tetrahedron, 54, pp.7465-7484.

Wilmouth, RC, Westwood, NJ, Anderson, K, Brownlee, W, Claridge, TDW, Clifton, IJ, Pritchard, GJ, Aplin, RT, Schofield, CJ (1998) Inhibition of Elastase by -suluphonyl β-lactams: Anatomy of a Stable Acyl-Enzyme Complex, Biochemistry, 37, pp.17506-17513.

Adlington, RM, Baldwin, JE, Chen, BN, Cooper, SL, McCoull, W, Pritchard, GJ, Howe, TJ, Becker, GW, Hermann, RB, McNulty, AM, Neubauer, BL (1997) Design and Synthesis of Novel Monocyclic Beta-Lactam Inhibitors of Prostate Specific Antigen, Bioorganic and Medicinal Chemistry Letters, 7, pp.1689-1694.

Smith, K, Lindsay, CM, Morris, IK, Matthews, I, Pritchard, GJ (1994) The Synthesis of 2-Substituted Thiazolo[5,4-c]pyridines Directed Metalation, Sulfur Letters, 17, pp.197-216.

Smith, K and Pritchard, GJ (1990) Carbonylation of Doubly Lithiated -pivaloylanilines. A Novel Approach to Dioxindoles Intramolecular Trapping of Aromatic Acyllithiums, Angewandte Chemie International Edition, 29, pp.282-283.

Smith, K, Lindsay, CM, Pritchard, GJ (1989) Directed Lithiation of Arenethiols, Journal of the American Chemical Society, 111, pp.656-669.

Smith, K, Lindsay, CM, Pritchard, GJ (1989) Directed lithiation of arenethiols, Journal of the American Chemical Society, 111(2), pp.665-669, ISSN: 0002-7863. DOI: 10.1021/ja00184a040.



Figures

Fernandez-Diaz-Ropero, B, Weaver, G, Pritchard, G (Accepted for publication) Support Information (NMR data) of New Functionalisation Chemistry 2- and 4-Pyridones and Related Heterocycles.



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