Loughborough University
Leicestershire, UK
LE11 3TU
+44 (0)1509 263171
Loughborough University

Loughborough University Research Publications


Publications for Robert Thomas

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Journal Articles

Beltran-Rendon, C, Price, CJ, Glen, K, Stacey, A, Barbaric, I, Thomas, RJ (2024) Modeling the selective growth advantage of genetically variant human pluripotent stem cells to identify opportunities for manufacturing process control, Cytotherapy, ISSN: 1465-3249. DOI: 10.1016/j.jcyt.2024.01.010.

Cheung, M, Campbell, J, Thomas, R, Braybrook, J, Petzing, J (2022) Assessment of automated flow cytometry data analysis tools within cell and gene therapy manufacturing, International Journal of Molecular Sciences, 23(6), 3224, DOI: 10.3390/ijms23063224.

Shariatzadeh, M, Lopes, AG, Glen, K, Sinclair, A, Thomas, R (2021) Application of a simple unstructured kinetic and cost of goods models to support T-cell therapy manufacture, Biotechnology Progress, 37(6), e3205, ISSN: 8756-7938. DOI: 10.1002/btpr.3205.

Shariatzadeh, M, Glen, KE, Thomas, RJ (2021) Multi-level modelling approach for cost effective t-cell manufacture, Cytotherapy, 23(5), pp.S198-S198, ISSN: 1465-3249. DOI: 10.1016/s1465324921006228.

Kusena, J, Shariatzadeh, M, Thomas, R, Wilson, S (2021) Understanding cell culture dynamics: a tool for defining protocol parameters for improved processes and efficient manufacturing using human embryonic stem cells, Bioengineered, 12(1), pp.979-996, ISSN: 2165-5979. DOI: 10.1080/21655979.2021.1902696.

Cheung, M, Campbell, J, Whitby, L, Thomas, R, Braybrook, J, Petzing, J (2021) Current trends in flow cytometry automated data analysis software, Cytometry Part A, 99(10), pp.1007-1021, ISSN: 1552-4922. DOI: 10.1002/cyto.a.24320.

Kusena, J, Shariatzadeh, M, Studd, A, James, JR, Thomas, R, Wilson, S (2021) The importance of cell culture parameter standardization: an assessment of the robustness of the 2102Ep reference cell line, Bioengineered, 12(1), pp.341-357, ISSN: 1949-1018. DOI: 10.1080/21655979.2020.1870074.

Da-Silva-Granja, C, Glen, K, Sandström, N, Ostanin, VP, Thomas, R, Ghosh, S (2020) A quartz crystal resonator for cellular phenotyping, Biosensors and Bioelectronics: X, 6, 100057, ISSN: 2590-1370. DOI: 10.1016/j.biosx.2020.100057.

Picken, A, Harriman, J, Iftimia-Mander, A, Johnson, L, Prosser, A, Quirk, R, Thomas, R (2020) A Monte Carlo framework for managing biological variability in manufacture of autologous cell therapy from mesenchymal stromal cells therapies, Cytotherapy, 22(4), pp.227-238, ISSN: 1465-3249. DOI: 10.1016/j.jcyt.2020.01.006.

Kusena, J, Thomas, R, McCall, M, Wilson, S (2019) From protocol to product: ventral midbrain dopaminergic neuron differentiation for the treatment of Parkinson's disease, Regenerative Medicine, 14(11), pp.1057-1069, ISSN: 1746-0751. DOI: 10.2217/rme-2019-0076.

Stacey, G, Andrews, PW, Asante, C, Barbaric, I, Barry, J, Bisset, L, Braybrook, J, Buckle, R, Chandra, A, Coffey, P, Crouch, S, Driver, P, Evans, A, Gardner, J, Ginty, PJ, Goldring, C, Hay, DC, Healy, L, Hows, A, Hutchinson, C, Jesson, H, Kalber, T, Kimber, SJ, Leathers, R, Moyle, S, Murray, T, Neale, M, Pan, D, Park, BK, Rebolledo, RE, Rees, I, Rivolta, MN, Ritchie, A, Roos, EJ, Saeb-Parsy, K, Schroder, B, Sebastian, S, Thomas, A, Thomas, R, Turner, M, Vallier, L, Vitillo, L, Webster, A, Williams, D (2018) Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop, Regen Med, DOI: 10.2217/rme-2018-0120.

Hallam, D, Hilgen, G, Dorgau, B, Zhu, L, Yu, M, Bojic, S, Hewitt, P, Schmitt, M, Uteng, M, Kustermann, S, Steel, D, Nicholds, M, Thomas, R, Treumann, A, Porter, A, Sernagor, E, Armstrong, L, Lako, M (2018) Human induced pluripotent stem cells generate light responsive retinal organoids with variable and nutrient dependent efficiency, Stem Cells, 36(10), pp.1535-1551, DOI: 10.1002/stem.2883.

Glen, K, Cheeseman, E, Stacey, AJ, Thomas, R (2018) A mechanistic model of erythroblast growth inhibition providing a framework for optimisation of cell therapy manufacturing, Biochemical Engineering Journal, 133, pp.28-38, ISSN: 1369-703X. DOI: 10.1016/j.bej.2018.01.033.

Stacey, AJ, Cheeseman, E, Glen, K, Moore, RLL, Thomas, R (2018) Experimentally integrated dynamic modelling for intuitive optimisation of cell based processes and manufacture, Biochemical Engineering Journal, 132, pp.130-138, ISSN: 1369-703X. DOI: 10.1016/j.bej.2018.01.012.

Moore, R, Worrallo, MJ, Mitchell, PD, Harriman, J, Glen, K, Thomas, R (2017) Immobilisation of Delta-like 1 ligand for the scalable and controlled manufacture of hematopoietic progenitor cells in a stirred bioreactor, BMC Biotechnol, 17(1), p.65, DOI: 10.1186/s12896-017-0383-0.

Bayley, R, Ahmed, F, Glen, K, McCall, M, Stacey, A, Thomas, R (2017) The productivity limit of manufacturing blood cell therapy in scalable stirred bioreactors, Journal of Tissue Engineering and Regenerative Medicine, ISSN: 1932-6254. DOI: 10.1002/term.2337.

Worrallo, MJ, Moore, RLL, Glen, KE, Thomas, RJ (2016) Immobilized hematopoietic growth factors onto magnetic particles offer a scalable strategy for cell therapy manufacturing in suspension cultures, Biotechnology Journal, 12(2), ISSN: 1860-6768. DOI: 10.1002/biot.201600493.

Williams, D, Archer, JR, Archibald, PRT, Bantounas, I, Baptista, R, Barker, R, Barry, J, Bietrix, F, Blair, N, Braybrook, J, Campbell, J, Canham, M, Chandra, A, Foldes, G, Gilmanshin, R, Girard, M, Gorjup, E, Hewitt, Z, Hourd, PC, Hyllner, J, Jesson, H, Kee, J, Kerby, J, Kotsopoulou, N, Kowalski, S, Leidel, C, Marshall, D, Masi, L, McCall, M, McCann, C, Medcalf, N, Moore, H, Ozawa, H, Pan, D, Parmar, M, Plant, AL, Reinwald, Y, Sebastian, S, Stacey, G, Thomas, R, Thomas, D, Thurman-Newell, JA, Turner, M, Vitillio, L, Wall, I, Wilson, A, Wolfrum, J, Yang, Y, Zimmerman, H (2016) Comparability: Manufacturing, characterization and controls, report of a UK Regenerative Medicine Platform Pluripotent Stem Cell Platform Workshop, Trinity Hall, Cambridge, 14-15 September 2015, Regenerative Medicine, 11(5), pp.483-492, ISSN: 1746-0751. DOI: 10.2217/rme-2016-0053.

Smith, D, Glen, K, Thomas, R (2015) Automated image analysis with the potential for process quality control applications in stem cell maintenance and differentiation, BIOTECHNOLOGY PROGRESS, 32(1), pp.215-223, ISSN: 8756-7938. DOI: 10.1002/btpr.2199.

Mitchell, PD, Ratcliffe, E, Hourd, P, Williams, DJ, Thomas, RJ (2014) A quality-by-design approach to risk reduction and optimization for human embryonic stem cell cryopreservation processes, Tissue Eng Part C Methods, 20(12), pp.941-950, DOI: 10.1089/ten.TEC.2013.0595.

Bayon, Y, Vertès, AA, Ronfard, V, Egloff, M, Snykers, S, Salinas, GF, Thomas, R, Girling, A, Lilford, R, Clermont, G, Kemp, P (2014) Translating Cell-Based Regenerative Medicines from Research to Successful Products: Challenges and Solutions, Tissue Engineering Part B: Reviews, 20(4), pp.246-256, ISSN: 1937-3368. DOI: 10.1089/ten.teb.2013.0727.

Soares, FAC, Chandra, A, Thomas, RJ, Pedersen, RA, Vallier, L, Williams, DJ (2014) Investigating the feasibility of scale up and automation of human induced pluripotent stem cells cultured in aggregates in feeder free conditions, J Biotechnol, 173, pp.53-58, DOI: 10.1016/j.jbiotec.2013.12.009.

Ratcliffe, E, Thomas, RJ, Stacey, AJ (2014) Visualizing medium and biodistribution in complex cell culture bioreactors using in vivo imaging, Biotechnol Prog, 30(1), pp.256-260, DOI: 10.1002/btpr.1840.

Iftimia-Mander, A, Hourd, P, Dainty, R, Thomas, RJ (2013) Mesenchymal stem cell isolation from human umbilical cord tissue: Understanding and minimizing variability in cell yield for process optimization, Biopreservation and Biobanking, 11(5), pp.291-298, ISSN: 1947-5535. DOI: 10.1089/bio.2013.0027.

Ratcliffe, E, Hourd, P, Guijarro-Leach, J, Rayment, E, Williams, DJ, Thomas, RJ (2013) Application of response surface methodology to maximize the productivity of scalable automated human embryonic stem cell manufacture, Regen Med, 8(1), pp.39-48, DOI: 10.2217/rme.12.109.

Glen, KE, Workman, VL, Ahmed, F, Ratcliffe, E, Thomas, RJ, Stacey, AJ (2013) Production of erythrocytes from directly isolated or Delta1 Notch ligand expanded CD34 hematopoietic progenitor cells: process characterization, monitoring and implications for manufacture, Cytotherapy, ISSN: 1465-3249. DOI: 10.1016/j.jcyt.2013.04.008.

Ratcliffe, E, Glen, KE, Workman, VL, Stacey, AJ, Thomas, RJ (2012) A novel automated bioreactor for scalable process optimisation of haematopoietic stem cell culture, J Biotechnol, 161(3), pp.387-390, DOI: 10.1016/j.jbiotec.2012.06.025.

Gould, T, Saeed, AO, Thomas, R, Rose, F, Shakesheff, K (2012) Technologies for live stem cell transportation, JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 6, pp.412-412, ISSN: 1932-6254.

Williams, DJ, Thomas, RJ, Hourd, PC, Chandra, A, Ratcliffe, E, Liu, Y, Rayment, EA, Archer, JR (2012) Precision manufacturing for clinical-quality regenerative medicines, Philos Trans A Math Phys Eng Sci, 370(1973), pp.3924-3949, ISSN: 1364-503X. DOI: 10.1098/rsta.2011.0049.

Thomas, R and Ratcliffe, E (2012) Automated adherent human cell culture (mesenchymal stem cells), Methods in Molecular Biology, 806, pp.393-406, ISSN: 1064-3745. DOI: 10.1007/978-1-61779-367-7_26.

Hewitt, CJ, Lee, K, Nienow, A, Thomas, RJ, Smith, M, Thomas, CR (2011) Expansion of human mesenchymal stem cells on microcarriers, Biotechnology Letters, 33, pp.2325-3335, DOI: 10.1007/s10529-011-0695-4.

Ratcliffe, E, Thomas, RJ, Williams, DJ (2011) Current understanding and challenges in bioprocessing of stem cell-based therapies for regenerative medicine, Br Med Bull, 100, pp.137-155, DOI: 10.1093/bmb/ldr037.

Gould, TWA, Thomas, RJ, Rose, FRAJ, Shakesheff, KM (2011) Cell life support system for transportation, European Cells and Materials, 22(SUPPL.3), p.62, ISSN: 1473-2262.

Thomas, RJ and Williams, DJ (2009) Large-Scale Manufacture of Therapeutic Human Stem Cells, Pharmaceutical Technology, 33(7), pp.74-79.

Thomas, RJ, Anderson, D, Chandra, A, Smith, NM, Young, LE, Williams, DJ, Denning, C (2009) Automated, Scalable Culture of Human Embryonic Stem Cells in Feeder-Free Conditions, Biotechnology and Bioengineering, 102(6), pp.1636-1644, DOI: 10.1002/bit.22187.

Thomas, RJ, Hope, AD, Hourd, P, Baradez, M, Miljan, EA, Sinden, JD, Williams, DJ (2009) Automated, serum-free production of CTX0E03: a therapeutic clinical grade human neural stem cell line, Biotechnology Letters, Online First, pp.1-6, ISSN: 1573-6776. DOI: 10.1007/s10529-009-9989-1.

Thomas, R (2009) Regenerative medicine: where are we at?, JOURNAL OF PHARMACY AND PHARMACOLOGY, 61, pp.A165-A165, ISSN: 0022-3573.

Mather, ML, Crowe, JA, Morgan, SP, White, LJ, Shakesheff, KM, Howdle, SM, Thomas, RJ, Byrne, HM, Waters, SL, Williams, DJ (2008) Remedi: A research consortium applying engineering strategies to establish regenerative medicine as a new industry, IFMBE Proceedings, 22, pp.2209-2212, ISSN: 1680-0737. DOI: 10.1007/978-3-540-89208-3_528.

Thomas, RJ, Hourd, P, Williams, DJ (2008) Application of process quality engineering techniques to improve the understanding of the in-vitro processing of stem cells for therapeutic use, Journal of Biotechnology, 136(3-4), pp.148-155, DOI: 10.1016/j.jbiotec.2008.06.009.

Thomas, RJ, Chandra, A, Hourd, P, Williams, DJ (2008) Cell Culture Automation and Quality Engineering: A Necessary Partnership to Develop Optimised Manufacturing Processes for Cell-Based Therapies, Journal of the Association of Laboratory Automation, 13(3), pp.152-158, DOI: 10.1016/j.jala.2007.12.003.

Thomas, RJ, Chandra, A, Liu, Y, Hourd, P, Conway, PP, Williams, DJ (2007) Manufacture of a human mesenchymal stem cell population using an automated cell culture platform, Cytotechnology, 55(1), pp.31-39, ISSN: 0920-9069. DOI: 10.1007/s10616-007-9091-2.

Thomas, RJ, Bennett, A, Thomson, B, Shakesheff, K (2006) Hapatic stellate cells on poly(DL-lactic acid) surfaces control the formation of 3D hepatocyte co-culture aggregates in vitro, European Cells and Materials, 11, pp.16-26.

Thomas, RJ, Bhandari, R, Barrett, DA, Bennett, AJ, Fry, JR, Powe, D, Thomson, BJ, Shakesheff, KM (2005) The effect of three-dimensional co-culture of hepatocytes and hepatic stellate cells on key hepatocyte functions in vitro, Cells, Tissues, Organs, 181(2), pp.67-79.

Thomas, R, Woon, ML, Ralevic, V, Alexander, SPH (2002) An investigation of the role of cyclic nucleotides and potassium channels in the ADP-induced relaxation of the porcine isolated coronary artery, BRITISH JOURNAL OF PHARMACOLOGY, 135, ISSN: 0007-1188.



Conferences

Li, R, Lyness, AM, Harriman, J, Glen, KE, Thomas, R, Molina, SA (2022) SINGLE- AND SPLIT-DOSE CRYOPRESERVATION OF T CELLS. In , CYTOTHERAPY, pp.S168-S169.

Cheung, M, Campbell, J, Thomas, R, Braybrook, J, Petzing, J (2022) Performance analysis of tools for automated flow cytometry data analysis within cell and gene therapy manufacturing [Poster]. In Midlands Innovation Flow Cytometry Meeting 2022, Loughborough, UK.

Cheung, M, Campbell, J, Thomas, R, Braybrook, J, Petzing, J (2022) Performance comparison of tools for automated flow cytometry data analysis within cell and gene therapy manufacturing [Abstract]. In Midlands Innovation Flow Cytometry Meeting 2022, Loughborough, UK.

Cheung, M, Campbell, J, Thomas, R, Braybrook, J, Petzing, J (2021) Assessment Of Computational Tools For Automated Flow Cytometry Data Analysis Within Cell And Gene Therapy Manufacturing. In Cheung, M and Petzing, J (ed) Future Leaders in Regenerative Medicine: Joint Conference CDTs and UKSB, Glasgow.

Molina, SA, Glen, KE, Harriman, J, Kraft, CL, Thomas, RJ, Lyness, AM (2021) EVALUATION OF A NOVEL CYCLIC OLEFIN POLYMER CONTAINER SYSTEM FOR CRYOPRESERVATION OF ADENO-ASSOCIATED VIRUS. In , CYTOTHERAPY, pp.S154-S154.

Molina, SA, Kraft, C, Glen, KE, Harriman, J, Singh, R, Cicarelli, J, Rafiq, QA, Thomas, RJ, Lyness, AM (2021) COMPARISON OF RIGID POLYMER VIALS AND FLEXIBLE BAGS FOR THE CRYOPRESERVATION OF T CELLS. In , CYTOTHERAPY, pp.S182-S182.

Cheung, M, Campbell, J, Braybrook, J, Thomas, R, Petzing, J (2020) Evaluation of flow cytometry automated data analysis platform performance for rare event detection. In EPSRC and MRC CDTs – Future Leaders Virtual Conference 2020, Virtual Conference.

Cheung, M, Campbell, J, Braybrook, J, Thomas, R, Petzing, J (2020) Benchmarking automated flow cytometry data analysis software using synthetic datasets. In International Society for Cell & Gene Therapy - ISCT 2020 Conference, Cytotherapy, Paris (Virtual), pp.538-539, DOI: 10.1016/j.jcyt.2020.03.035.

Glen, KE, Stacey, A, Thomas, RJ (2020) Understanding cell culture medium dynamics as a key stepping stone to optimistation of cell therapy bioprocessing. In , CYTOTHERAPY, pp.S145-S145.

Thomas, R, Glen, KE, Stacey, A, Holland, P, Shariatzadeh, M (2020) Efficient design of cell based product manufacturing using low data demand modelling approaches. In , Cytotherapy, pp.S160-S160, DOI: 10.1016/j.jcyt.2020.03.333.

Kraft, C, Glen, KE, Harriman, J, Thomas, R, Lyness, AM (2020) Evaluation of a novel cyclic olefin polymer container system for cryopreservation of adeno-associated virus. In , CYTOTHERAPY, pp.S147-S148.

Shariatzadeh, M, Glen, KE, Rafiq, QA, Thomas, RJ (2020) An ode model for optimal operation of T-cell culture in suspension system. In , Cytotherapy, pp.S159-S159, DOI: 10.1016/j.jcyt.2020.03.330.

Cheung, M, Braybrook, J, Thomas, R, Campbell, J, Petzing, J (2019) Evaluating flow cytometry automated data analysis software in cell therapy manufacturing. In 16th Annual bioProcessUK Conference, Liverpool.

Hewitt, P, Schmitt, MW, Uteng, M, Kustermann, S, Pognan, F, Nicholds, M, Chichagova, V, Sernagor, E, Thomas, R, Kilbride, P, Armstrong, L, Lako, L (2019) Retinal-3D: Development of 3D eye models for early assessment of retinal toxicity. A CRACK-IT Challenge. In , TOXICOLOGY LETTERS, pp.S36-S36.

Shariatzadeh, M and Thomas, RJ (2019) Mechanistic modelling for T cell therapy manufacture. In , HUMAN GENE THERAPY, pp.A28-A29.

Lyness, AM, Picken, A, Thomas, R (2019) EVALUATION OF A VIAL ADAPTOR TO ENSURE SAFE AND EFFICIENT NEEDLE-FREE TRANSFER OF CELLS POST-CRYOPRESERVATION IN PREPARATION FOR DRUG DELIVERY. In , CYTOTHERAPY, pp.S38-S39, DOI: 10.1016/j.jcyt.2019.03.374.

Cheung, M, Campbell, J, Braybrook, J, Thomas, R, Petzing, J (2019) Flow cytometry automated data analysis software [abstract]. In EPSRC and MRC CDTs in Tissue Engineering and Regenerative Medicine 2019 Joint Conference, University of Manchester, Manchester, UK.

Chichagova, V, Hallam, D, Nicholds, M, Thomas, R, Lako, M, Armstrong, L (2018) Using statistical models to identify key variables critical for generation of retinal organoids from iPSC. In , INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.

Lyness, AM, Kraft, CL, Picken, A, Harriman, J, Thomas, R (2018) EVALUATION OF A NOVEL CYCLIC OLEFIN POLYMER CONTAINER SYSTEM FOR THE CRYOPRESERVATION OF ADHERENT AND SUSPENSION HUMAN CELL TYPES. In , CYTOTHERAPY, pp.S67-S67, DOI: 10.1016/j.jcyt.2018.02.188.

Mitchell, W, Thomas, R, McCall, M (2018) FIRST STEPS TOWARDS UNDERSTANDING CELL LOSSES IN DOWNSTREAM PROCESSING. In , CYTOTHERAPY, pp.S68-S68, DOI: 10.1016/j.jcyt.2018.02.190.

Kusena, J, Wilson, S, Thomas, R, McCall, M (2018) TRANSLATIONAL REQUIREMENTS FOR ENHANCED CHARACTERISATION OF MANUFACTURED DOPAMINERGIC NEURONS FOR THE TREATMENT OF PARKINSON'S DISEASE. In , CYTOTHERAPY, pp.S66-S67, DOI: 10.1016/j.jcyt.2018.02.186.

Thomas, R, Glen, K, Moore, R, Cheeseman, E, Stacey, A (2017) Dynamic Mechanistic Modelling for Optimisation of Therapeutic Cell Culture Processes. In , HUMAN GENE THERAPY, pp.A15-A16.

Sebastian, S, Chandra, A, Hourd, PC, Wilson, S, McCall, M, Medcalf, N, Thomas, R, Williams, D (2017) Pluripotent stem cell based medicinal products: A case study of process transfer related technical and manufacturing issues [Abstract]. In , CYTOTHERAPY. DOI: 10.1016/j.jcyt.2017.02.211.

Shariatzadeh, M, Wilson, S, Chandra, A, Sebastian, S, McCall, M, Thomas, R, Medcalf, N, Hewitt, Z, Williams, D (2017) Quality approaches to allow multi-site equivalence in pluripotent stem cell based product manufacturing [Abstract]. In , Royal Welsh Coll Mus & Drama, Cardiff, WALES. DOI: 10.1089/hum.2017.29044.abstracts.

Moore, R, Worrallo, M, Glen, K, Thomas, R (2016) SCALABLE, CONTROLLED AND COST EFFECTIVE PRESENTATION OF SURFACE IMMOBILISED FACTORS FOR HAEMATOPOLETIC CELL EXPANSION. In , CYTOTHERAPY, pp.S29-S30.

Worrallo, M, Moore, R, Glen, K, Thomas, R (2016) The Use of Immobilized Growth Factors in Standard Scalable Bioreactors for Cord Blood CD34+Expansion. In , TRANSFUSION, pp.5A-5A.

Cheeseman, EA, Moore, R, McCall, M, Ahmed, F, Moreau, T, Ghevaert, C, Thomas, R (2016) Enabling Human Pluripotent Stem Cell Derived Megakaryocyte Manufacture. In ISCT, Cytotherapy, Singapore, pp.S17-S17.

Turner, M, Mountford, J, Forrester, L, Ghevaert, C, Thomas, R, Anstee, D, Murphy, W, Courtney, A, Thompson, K (2014) PROGRESS TOWARDS THE CGMP PRODUCTION OF PLURIPOTENT STEM CELL DERIVED RED BLOOD CELLS. In , CYTOTHERAPY, pp.S16-S16, DOI: 10.1016/j.jcyt.2014.01.041.

Williams, DJ, Guijarro-Leach, JJ, Ratcliffe, E, Denning, C, Thomas, RJ, Young, L (2011) Investigating the Consistent Scaled Processing of Human Embryonic Stem Cells (2.P6). In TERMIS-EU 2011, Histology and Histopathology: cellular and molecular biology, Granada, Spain, pp.29-29.

Williams, DJ, Iftimia, AD, Irving, J, Thomas, RJ (2011) Optimization of Processing and Expansion for Mesenchymal Stem Cells from Umbilical Cord Tissue (48.P5). In TERMIS-EU 2011, Histology and Histopathology: cellular and molecular biology, Granada, Spain, pp.397-397.

Thomas, RJ, Drake, R, Hourd, P, Liu, Y, Chandra, A, Williams, DJ (2010) Automated Manufacture of Stem Cells for Regenerative Medicine Applications. In TERMIS-EU 2010 Galway, Galway, Northern Ireland, pp.136-136.

Mather, ML, Crowe, JA, Thomas, RJ, Waters, SL, Byrne, HM (2008) Mathematical Investigation of Population Variability in Neural Stem Cells. In Meeting of the Tissue and Cell Engineering Society (TCES) 2-4 July 2008, European Cells & Materials Journal, University of Nottingham, UK, p.81.

Singh, P, Thomas, RJ, Williams, DJ (2008) (OP 21) Automated Culture of Umbilical Cord Blood Derived Progenitor Cells. In Termis EU 2008, Tissue Engineering: Part A: Meeting Abstracts, Porto, Portugal, p.701, DOI: 10.1089/tea.2008.1504.

Thomas, RJ, Chandra, A, Hourd, P, Williams, DJ (2008) (OP 22) Automation, Scale-up and Process Engineering: Essentials for Successful Translation of Cell Based Therapies. In Termis EU 2008, Tissue Engineering: Part A: Meeting Abstracts, Porto, Portugal, pp.701-702, DOI: 10.1089/tea.2008.1504.

Singh, P, Thomas, RJ, Williams, DJ (2008) Automated culture of umbilical cord blood derived progenitor cells. In Annual Tissue-Engineering-and-Regenerative-Medicine-International-Society-European-Chapter Meeting, TISSUE ENGINEERING PART A, Porto, PORTUGAL, pp.701-701.

Thomas, RJ, Chandra, A, Hourd, PC, Williams, DJ (2008) Automation, scale-up and process engineering: Essentials for successful translation of cell based therapies. In Annual Tissue-Engineering-and-Regenerative-Medicine-International-Society-European-Chapter Meeting, TISSUE ENGINEERING PART A, Porto, PORTUGAL, pp.701-702.

Thomas, RJ, Chandra, A, Williams, DJ (2007) Culture of Human Mesenchymal Stem Cells Using a Novel Automated Cell Culture Platform. In Termis NA 2007, Proceedings of Termis NA 2007, Toronto, Canada.

Hammond, JS, Thomas, R, Barry, J, Beckingham, IJ, Shakesheff, KM (2005) Synthesis of functional liver tissue using a novel tissue engineering strategy. In , HEPATOLOGY, pp.506A-507A.



School/Dept Working Papers

Hourd, P and Thomas, RJ (2007) hMSC Process DOE Design.

Hourd, P and Thomas, RJ (2007) hMSC DOE Experimental Details.

Thomas, RJ and Hourd, P (2007) Process Characterisation of the Automated Cell Culture of MSCs (CompacT SelecT): Process Map.

Liu, Y, Hourd, P, Thomas, RJ, Shakesheff, K, Archer, R, Williams, DJ (2006) Challenges of Culturing Functioning Cells in-vitro for Regenerative Medicine and Stem Cell Therapy from a Process Perspective.

Thomas, RJ, Liu, Y, Chandra, A, Hourd, P, Williams, DJ (2006) Automated hMSC Culture Using the Compact SelecT.



Patents

McCall, MJS and Thomas, RJ (2015) Cell Culture System.

McCall, MJS and Thomas, RJ (2014) Cell Culture System.

McCall, MJS, Thomas, R, Sagar, S, White, J (Accepted for publication) Semi-automatic pipette.



Posters

Cheung, M, Campbell, J, Braybrook, J, Thomas, R, Petzing, J (2019) Evaluating flow cytometry automated data analysis software [poster].

Glen, KE, Stacey, A, Thomas, R (2017) MODELLING PRODUCTIVITY TO OPTIMISE RED BLOOD CELL MANUFACTURE FROM HAEMATOPOLETIC STEM CELLS.

Cheeseman, E, Glen, KE, Moore, R, McCall, M, Moreau, T, Ghevaert, C, Stacey, A, Thomas, R (2017) ENABLING HUMAN PLURIPOTENT STEM CELL DERIVED MEGAKARYOCYTE MANUFACTURE.

Moore, R, Glen, KE, Worrallo, M, Thomas, R (2017) IMMOBILISED PROTEINS FOR THE LINEAGE CONTROL OF HEMATOPOIETIC STEM CELLS DURING EXPANSION.

Mitchell, P, Cheeseman, E, Harriman, J, Glen, KE, McCall, M, Thomas, R (2017) ANEW AUTOMATED VIAL THAWER CONTROLS THE THAWING OF CRYOPRESERVED MESENCHYMAL STEM CELLS TO ACHIEVE HIGH CELL VIABILITY AND GROWTH POTENTIAL.

Mitchell, P, Cheeseman, E, Harriman, J, Glen, KE, McCall, M, Thomas, R (2017) A new automated vial thawer controls the thawing of cryopreserved mesenchymal stem cells to achieve high cell viability and growth potential, ISCT.



Getting in touch

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