Journal Articles
Teixeira, R, Andresini, M, Luisi, R,
Benyahia, B (2024)
Computer-Aided Retrosynthesis for Greener and Optimal Total Synthesis of a Helicase-Primase Inhibitor Active Pharmaceutical Ingredient,
JACS Au, ISSN: 2691-3704. DOI:
10.1021/jacsau.4c00624.
Liu, J and
Benyahia, B (2024)
Single and multi-objective shutdown optimization of a multistage continuous crystallizer,
Industrial and Engineering Chemistry Research, ISSN: 0888-5885. DOI:
10.1021/acs.iecr.3c03441.
Li, W, Hatcher, LE, Wilson, CC, Rielly, C,
Benyahia, B (2023)
A framework for systematic crystal shape tuning – case of Lovastatin's needle-shaped crystals,
Chemical Engineering Research and Design, 202, pp.126-146, ISSN: 0263-8762. DOI:
10.1016/j.cherd.2023.12.016.
Lackowska, I, Vladisavljevic, G, Dragosavac, M,
Benyahia, B (2023)
Production and tuning of spherical agglomerates of benzoic acid using membrane dispersion systems,
Crystal Growth and Design, 23(12), ISSN: 1528-7483. DOI:
10.1021/acs.cgd.3c00963.
Urwin, SJ, Chong, MWS, Li, W, McGinty, J, Mehta, B, Ottoboni, S, Pathan, M, Prasad, E, Robertson, M, McGowan, M, al-Attili, M, Gramadnikova, E, Siddique, M, Houson, I, Feilden, H,
Benyahia, B, Brown, CJ, Halbert, GW, Johnston, B, Nordon, A, Price, CJ, Rielly, C, Sefcik, J, Florence, AJ (2023)
Digital process design to define and deliver pharmaceutical particle attributes,
Chemical Engineering Research and Design, 196, pp.726-749, ISSN: 0263-8762. DOI:
10.1016/j.cherd.2023.07.003.
Sun, Z, Quon, J, Papageorgiou, C,
Benyahia, B, Rielly, C (2022)
Use of wet milling combined with temperature cycling to minimize crystal agglomeration in a sequential antisolvent-cooling crystallization,
Crystal Growth & Design, 22(8), pp.4730-4744, ISSN: 1528-7483. DOI:
10.1021/acs.cgd.1c01510.
Liu, J and
Benyahia, B (2022)
Optimal start-up strategies of a combined cooling and antisolvent multistage continuous crystallization process,
Computers and Chemical Engineering, 159, 107671, ISSN: 0098-1354. DOI:
10.1016/j.compchemeng.2022.107671.
Benyahia, B, Bandulasena, M, Bandulasena, H, Vladisavljevic, G (2021) Experimental and computational analysis of mixing inside droplets for microfluidic fabrication of gold nanoparticles,
Industrial and Engineering Chemistry Research, ISSN: 0888-5885.
Benyahia, B, Anandan, P, Rielly, C (2021) Control of Batch and Continuous Crystallization Processes using Reinforcement Learning,
Computer Aided Chemical Engineering, pp.1371-1376.
Benyahia, B and Liu, J (2021) Systematic model-based dynamic optimization of a combined cooling and antisolvent multistage continuous crystallization process,
Computer Aided Chemical Engineering.
Hatcher, LE, Li, W, Payne, P,
Benyahia, B, Rielly, C, Wilson, CC (2020)
Tuning morphology in active pharmaceutical ingredients: controlling the crystal habit of lovastatin through solvent choice and non-size-matched polymer additives,
Crystal Growth & Design, 20(9), pp.5854-5862, ISSN: 1528-7483. DOI:
10.1021/acs.cgd.0c00470.
Fayemiwo, K, Chiarasumran, N, Nabavi, SA, Manović, V,
Benyahia, B, Vladisavljevic, G (2019)
CO2 capture performance and environmental impact of copolymers of ethylene glycol dimethacrylate with acrylamide, methacrylamide and triallylamine,
Journal of Environmental Chemical Engineering, 8(2), 103536, ISSN: 2213-3437. DOI:
10.1016/j.jece.2019.103536.
Fayemiwo, K, Chiarasumran, N, Nabavi, SA, Loponov, K, Manovic, V,
Benyahia, B, Vladisavljevic, G (2019)
Eco-friendly fabrication of highly selective amide-based polymer for CO2 capture,
Industrial and Engineering Chemistry Research, 58(39), pp.18160-18167, ISSN: 0888-5885. DOI:
10.1021/acs.iecr.9b02347.
Bandulasena, MV, Vladisavljevic, G,
Benyahia, B (2019)
Versatile reconfigurable glass capillary microfluidic devices with Lego® inspired blocks for drop generation and micromixing,
Journal of Colloid and Interface Science, 542, pp.23-32, ISSN: 0021-9797. DOI:
10.1016/j.jcis.2019.01.119.
Brumano, LP, da Silva, FVS, Costa-Silva, TA, Apolinario, AC, Santos, JHP, Kleingesinds, EK, Monteiro, G, Rangel-Yagui, CD,
Benyahia, B, Junior, AP (2019)
Development of L-Asparaginase biobetters: Current research status and review of the desirable quality profiles,
Fontiers, 6(212), ISSN: 2296-4185. DOI:
10.3389/fbioe.2018.00212.
Bandulasena, M, Vladisavljevic, G,
Benyahia, B (2018)
Droplet-based microfluidic method for robust preparation of gold nanoparticles in axisymmetric flow focusing device,
Chemical Engineering Science, 195, pp.657-664, ISSN: 0009-2509. DOI:
10.1016/j.ces.2018.10.010.
Fysikopoulos, D,
Benyahia, B, Borsos, A, Nagy, Z, Rielly, C (2018)
A framework for model reliability and estimability analysis of crystallization processes with multi-impurity multi-dimensional population balance models,
Computers & Chemical Engineering, 122, pp.275-292, ISSN: 0098-1354. DOI:
10.1016/j.compchemeng.2018.09.007.
Mansouri, SS, Udugama, IA, Huusom, JK, Gernaey, KV,
Benyahia, B (2018)
A shortcut approach for decision-making and operational analysis of an integrated end-to-end continuous pharmaceutical process, 44, pp.2107-2112, ISSN: 1570-7946. DOI:
10.1016/B978-0-444-64241-7.50346-3.
Onyemelukwe, I,
Benyahia, B, Reis, NM, Nagy, Z, Rielly, C (2018)
The heat transfer characteristics of a mesoscale continuous oscillatory flow crystalliser with smooth periodic constrictions,
International Journal of Heat and Mass Transfer, 123, pp.1109-1119, ISSN: 0017-9310. DOI:
10.1016/j.ijheatmasstransfer.2018.03.015.
Ramin, P, Mansouri, SS, Udugama, IA,
Benyahia, B, Gernaey, KV (2018)
Modelling continuous pharmaceutical and bio-based processes at plant-wide level: A roadmap towards efficient decision-making,
Chemistry Today, 36(2), pp.26-30, ISSN: 0392-839X.
Fayemiwo, K, Vladisavljevic, G, Nabavi, SA,
Benyahia, B, Hanak, DP, Loponov, K, Manovic, V (2017)
Nitrogen-rich hyper-crosslinked polymers for low-pressure CO2 capture,
Chemical Engineering Journal, 334, pp.2004-2013, ISSN: 1385-8947. DOI:
10.1016/j.cej.2017.11.106.
Bandulasena, M, Vladisavljevic, G, Odunmbaku, OG,
Benyahia, B (2017)
Continuous synthesis of PVP stabilized biocompatible gold nanoparticles with a controlled size using a 3D glass capillary microfluidic device,
Chemical Engineering Science, 171, pp.233-243, ISSN: 0009-2509. DOI:
10.1016/j.ces.2017.05.035.
Lakerveld, R,
Benyahia, B, Heider, PL, Zhang, H, Wolfe, A, Testa, CJ, Ogden, S, Hersey, DR, Mascia, S, Evans, JMB, Braatz, RD, Barton, PI (2015)
The Application of an Automated Control Strategy for an Integrated Continuous Pharmaceutical Pilot Plant,
Organic Process Research and Development, 19(9), pp.1088-1100, ISSN: 1083-6160. DOI:
10.1021/op500104d.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F (2015)
Optimized production of multilayered monodisperse polymer nanoparticles,
Computer Aided Chemical Engineering, 37, pp.863-868.
Hreiz, R, Roche, N,
Benyahia, B, Latifi, MA (2015)
Multi-objective optimization of large-size wastewater treatment plants operation and design,
Computer Aided Chemical Engineering, 37, pp.2495-2500.
Rainier, H, Roche, N,
Benyahia, B, Latifi, MA (2015)
Multi-objective optimal control of small-size wastewater treatment plants,
Chemical Engineering Research and Design, 102, pp.345-353, ISSN: 0263-8762. DOI:
10.1016/j.cherd.2015.06.039.
Su, Q,
Benyahia, B, Nagy, Z, Rielly, C (2015)
Mathematical modeling, design, and optimization of a multisegment multiaddition plug-flow crystallizer for antisolvent crystallizations,
ORGANIC PROCESS RESEARCH & DEVELOPMENT, 19(12), pp.1859-1870, ISSN: 1083-6160. DOI:
10.1021/acs.oprd.5b00110.
Paulen, R,
Benyahia, B, Latifi, MA, Fikar, M (2014)
Analysis of optimal operation of a fed-batch emulsion copolymerization reactor used for production of particles with core-shell morphology,
Computers and Chemical Engineering, 66, pp.233-243, ISSN: 0098-1354. DOI:
10.1016/j.compchemeng.2014.02.021.
Heider, PL, Born, SC, Basak, S,
Benyahia, B, Lakerveld, R, Zhang, H, Hogan, R, Buchbinder, L, Wolfe, A, Mascia, S, Evans, JMB, Jamison, TF, Jensen, KF (2014)
Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical,
Organic Process Research & Development, 18(3), pp.402-409, ISSN: 1083-6160. DOI:
10.1021/op400294z.
Lakerveld, R,
Benyahia, B, Heider, PL, Zhang, H, Braatz, RD, Barton, PI (2013)
Averaging Level Control to Reduce Off-Spec Material in a Continuous Pharmaceutical Pilot Plant,
Processes, 1(3), pp.330-348, DOI:
10.3390/pr1030330.
Mascia, S, Heider, PL, Zhang, H, Lakerveld, R,
Benyahia, B, Barton, PI, Braatz, RD, Cooney, CL, Evans, JMB, Jamison, TF, Jensen, KF, Myerson, AS, Trout, BL (2013)
End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation,
Angewandte Chemie International Edition, 52(47), pp.12359-12363, ISSN: 1433-7851. DOI:
10.1002/anie.201305429.
Lakerveld, R,
Benyahia, B, Braatz, RD, Barton, PI (2013)
Model-based design of a plant-wide control strategy for a continuous pharmaceutical plant,
AIChE Journal, 59(10), pp.3671-3685, ISSN: 0001-1541. DOI:
10.1002/aic.14107.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F (2013)
Emulsion copolymerization of styrene and butyl acrylate in the presence of a chain transfer agent. Part 2: Parameters estimability and confidence regions,
Chemical Engineering Science, 90, pp.110-118, ISSN: 0009-2509. DOI:
10.1016/j.ces.2012.12.013.
Zhou, L, Su, M,
Benyahia, B, Singh, A, Barton, PI, Trout, BL, Myerson, AS, Braatz, RD (2013)
Mathematical modeling and design of layer crystallization in a concentric annulus with and without recirculation,
AIChE Journal, 59(4), pp.1308-1321, ISSN: 0001-1541. DOI:
10.1002/aic.14049.
Paulen, R,
Benyahia, B, Latifi, MA, Fikar, M (2013)
Dynamic optimization of semi-batch emulsion co-polymerization reactor for styrene/butyl acrylate in the presence of a chain transfer agent,
Computer Aided Chemical Engineering, 32, pp.721-726, ISSN: 1570-7946. DOI:
10.1016/B978-0-444-63234-0.50121-4.
Benyahia, B, Lakerveld, R, Barton, PI (2012)
A plant-wide dynamic model of a continuous pharmaceutical process,
Industrial and Engineering Chemistry Research, 51(47), pp.15393-15412, ISSN: 0888-5885. DOI:
10.1021/ie3006319.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F (2011)
Multicriteria dynamic optimization of an emulsion copolymerization reactor,
Computers and Chemical Engineering, 35(12), pp.2886-2895, ISSN: 0098-1354. DOI:
10.1016/j.compchemeng.2011.05.014.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F (2011)
Modeling of a batch emulsion copolymerization reactor in the presence of a chain transfer agent. Estimability analysis, parameters identification and experimental validation,
Computer Aided Chemical Engineering, 29, pp.126-130, ISSN: 1570-7946. DOI:
10.1016/B978-0-444-53711-9.50026-2.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F (2011)
Modeling and multiobjective optimization of a fed-batch emulsion copolymerization process to control the resulting particles core-shell morphology,
Macromolecular Symposia, 302(1), pp.142-150, ISSN: 1022-1360. DOI:
10.1002/masy.201000071.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F, Nacef, S (2010)
Emulsion copolymerization of styrene and butyl acrylate in the presence of a chain transfer agent. Part 1: Modelling and experimentation of batch and fedbatch processes,
Chemical Engineering Science, 65(2), pp.850-869, ISSN: 0009-2509. DOI:
10.1016/j.ces.2009.09.036.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F (2010)
Multicriteria dynamic optimization of an emulsion copolymerization reactor,
Computer Aided Chemical Engineering, 28(C), pp.457-462, ISSN: 1570-7946. DOI:
10.1016/S1570-7946(10)28077-X.
Conferences
Teixeira, R and
Benyahia, B (2024)
The interplay between computer-aided retrosynthesis and flow chemistry for the effective greener-by-design synthesis of active pharmaceutical ingredient. In
27th International Congress of Chemical and Process Engineering (CHISA); 27th International Congress of Chemical and Process Engineering (CHISA), Prague, Czech Republic, 25th - 29th August 2024, Prague, Czech Republic.
Teixeira, R and
Benyahia, B (2024)
Computer-assisted retrosynthesis of active pharmaceutical ingredients glows green with photochemistry [Abstract]. In
29th IUPAC Symposium on Photochemistry (PhotoIUPAC 2024), Valencia, Spain.
Teixeira, R and
Benyahia, B (2024)
Computer-aided retrosynthesis strategies to control the crystallization impurities of the mefenamic acid [Abstract]. In
British Association for Crystal Growth's Conference (BACG 2024), Loughborough, UK.
Mehta, N and
Benyahia, B (2024)
Combining a high-throughput platform and AI for efficient crystallisation screening and tuning of crystal habit [Abstract]. In
The British Association for Crystal Growth (BACG) 2024, Loughbrough, UK.
Yewale, A, Yang, Y, Nazemifard, N, Charles
D. Papageorgiou, CDP, Rielly, C,
Benyahia, B (2024)
Multi-objective reinforcement learning for self-optimization of flow chemistry [Abstract]. In
34th European Symposium on Computer Aided Process Engineering (ESCAPE34) and PSE 24, Florence, Italy.
Bouchkira, I and
Benyahia, B (2024)
Multi objective optimization approach for enhancing flexibility of a pharmaceutical tableting process [Abstract]. In
34th European Symposium on Computer Aided Process Engineering (ESCAPE34) and PSE 24, Florence, Italy.
Campbell, T, Rielly, C,
Benyahia, B (2024)
Sustainability and quality-by-design of an integrated end-to-end continuous pharmaceutical plant [Abstract]. In
34th European Symposium on Computer Aided Process Engineering (ESCAPE34) and PSE 24, Florence, Italy.
Yuan, X and
Benyahia, B (2024)
A holistic approach for multi-objective design of experiment, model discrimination, and self-optimization of batch and continuous crystallization processes [Abstract]. In
34th European Symposium on Computer Aided Process Engineering (ESCAPE34) and PSE 24, Florence, Italy.
Salazar-Villacis, P and
Benyahia, B (2024) Non-Parametric Models for Yield Prediction in a Suzuki-Miyaura Coupling. In
34th European Symposium on Computer Aided Process Engineering (ESCAPE34) and PSE 24, Florence, Italy.
Teixeira, R and
Benyahia, B (2024)
Towards more effective greener-by-design multistep synthesis of Active Pharmaceutical Ingredients – the interplay between computer-aided retrosynthetic and flow chemistry [Abstract]. In
ChemEngDayUK24, London, UK.
Teixeira, R and
Benyahia, B (2023)
Computer-aided retrosynthesis planning for greener and optimal synthesis of APIs. In
LatinXChem 2023, Online.
Teixeira, R and Benyahia, B (Accepted for publication) Computer-aided retrosynthesis planning for greener and optimal synthesis of an active pharmaceutical ingredient [Extended abstract]. In 14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology (ECCE&ECAB 2023), Berlin, Germany.
Yewale, A, Rielly, C,
Benyahia, B (2023)
Reinforcement learning strategy for the optimization of flow chemistry [Extended abstract]. In
14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology (ECCE&ECAB 2023), Berlin, Germany.
Benyahia, B and Lackowska, I (2023)
A novel membrane system for precision spherical agglomeration of pharmaceuticals [Extended abstract]. In
14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology (ECCE&ECAB 2023), Berlin, Germany.
Campbell, T, Rielly, C,
Benyahia, B (2023)
A model-based strategy for the selection of the critical process parameters in integrated continuous pharmaceutical manufacturing [Extended abstract]. In
14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology (ECCE&ECAB 2023), Berlin, Germany.
Li, W,
Benyahia, B, Rielly, C (2023)
Design and optimization of a multi-stage continuous crystallization process for shape and size control in presence of impurities [Extended abstract]. In
14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology (ECCE&ECAB 2023), Berlin, Germany.
Liu, J and
Benyahia, B (2023)
A framework for the design steady state and dynamic optimization of multistage continuous crystallization of pharmaceuticals [Extended abstract]. In
14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology (ECCE&ECAB 2023), Berlin, Germany.
Yuan, X and
Benyahia, B (2023)
Novel model-based design of experiments strategies for batch and continuous crystallization of pharmaceuticals [Extended abstract]. In
14th European Congress of Chemical Engineering and 7th European Congress of Applied Biotechnology (ECCE&ECAB 2023), Berlin, Germany.
Liu, J and
Benyahia, B (2022) Multi-Objective Superstructure Optimization of an Integrated Continuous Multistage Reaction and Crystallization Process with Recycles. In
The 33rd European Symposium on Computer Aided Process Engineering (ESCAPE33), Athens, Greece.
Gao, S and Benyahia, B (Accepted for publication) Technoeconomic and Life Cycle Assessment of an mRNA Vaccine Integrated Manufacturing Plant. In The 33rd European Symposium on Computer Aided Process Engineering (ESCAPE33), Athens, Greece.
Bouchkira, I, Latifi, MA,
Benyahia, B (2022) ESTAN – A toolbox for global sensitivity based estimability analysis. In
The 33rd European Symposium on Computer Aided Process Engineering (ESCAPE33), Athens, Greece.
Meng, Q, Anandan, PD, Rielly, CD,
Benyahia, B (2022) Multi-Agent Reinforcement Learning and RL-Based Adaptive PID Control of Crystallization Processes. In
The 33rd European Symposium on Computer Aided Process Engineering (ESCAPE33), Athens, Greece.
Bouchkira, I, Latifi, MA,
Benyahia, B (2022) Multi-Objective Model-based Design of Experiments of Pharmaceutical Tableting Process. In
the 33rd European Symposium on Computer Aided Process Engineering (ESCAPE 33), Athens, Greece.
Campbell, T, Rielly, C,
Benyahia, B (2022)
Digital design and optimization of an integrated reaction-extraction-crystallization-filtration continuous pharmaceutical process. In Montastruc, L and Negny, S (ed)
32nd European Symposium on Computer Aided Process Engineering (ESCAPE32); 32nd European Symposium on Computer Aided Process Engineering: ESCAPE-32, Toulouse, France, pp.775-780, ISBN: 9780323958790. DOI:
10.1016/B978-0-323-95879-0.50130-2.
Anandan, P, Rielly, C,
Benyahia, B (2022)
Optimal control policies of a crystallization process using inverse reinforcement learning. In Montastruc, L and Negny, S (ed)
32nd European Symposium on Computer Aided Process Engineering (ESCAPE32); 32nd European Symposium on Computer Aided Process Engineering: ESCAPE-32, Toulouse, France, pp.1093-1098, ISBN: 9780323958790. DOI:
10.1016/B978-0-323-95879-0.50183-1.
Liu, J and
Benyahia, B (2022)
Combined optimization of start-up shutdown and grade transition of a multistage continuous crystallization process. In Montastruc, L and Negny, S (ed)
32nd European Symposium on Computer Aided Process Engineering (ESCAPE32); 32nd European Symposium on Computer Aided Process Engineering: ESCAPE-32, Toulouse, France, pp.181-186, ISBN: 9780323958790. DOI:
10.1016/B978-0-323-95879-0.50031-X.
Li, W,
Benyahia, B, Rielly, C (2022)
Model driven crystallization design and development for mefenamic acid [Abstract]. In
27th International Workshop on Industrial Crystallization (BIWIC 2022), Espoo, Finland.
Benyahia, B (2022)
A Quality by Digital Design framework for pharmaceuticals and biopharmaceuticals. In
32nd European Symposium on Computer Aided Process Engineering (ESCAPE32), Toulouse, France.
Lackowska, I, Dragosavac, M,
Benyahia, B (2022)
Comparative investigation of membrane systems for crystallization and spherical agglomeration. In
3rd International Online Conference on Crystals; Chemistry Proceedings, Online. DOI:
10.3390/IOCC_2022-12162.
Li, W, Rielly, C,
Benyahia, B (2022)
Targeting desired particle size for improved dissolution and manufacturability of mefenamic acid. In
3rd International Online Conference on Crystals; Chemistry Proceedings, Online. DOI:
10.3390/IOCC_2022-12165.
Liu, J and
Benyahia, B (2022)
Techno-economic evaluation and optimization of batch, fed-batch and multistage continuous crystallization processes. In
3rd International Online Conference on Crystals; Chemistry Proceedings, Online. DOI:
10.3390/IOCC_2022-12144.
Benyahia, B, Anandan, PD, Rielly, C (2021)
Robust Model-Based Reinforcement Learning Control of a Batch Crystallization Process. In
2021 9th International Conference on Systems and Control (ICSC), pp.89-94, DOI:
10.1109/icsc50472.2021.9666494.
Lackowska, I, Dragosavac, M,
Benyahia, B (2021)
Spherical agglomeration of benzoic acid using membrane emulsification. In
4th International Symposium on Pharmaceutical Engineering Research; SPhERe Proceedings : 4th International Symposium on Pharmaceutical Engineering Research, Online, pp.32-35, DOI:
10.24355/dbbs.084-202110251313-0.
Brown, CJ, Mitchell, NA, Doerr, F, McGinty, J, Chong, MWS, Robertson, M, Ottoboni, S, Li, W, Sefcik, J, Nordon, A, Johnston, B, Price, CJ, Rielly, C, Benyahia, B, Florence, AJ (Accepted for publication) Digital design of end-to-end manufacturing process for mefenamic acid using mechanistic modelling. In 21st International Symposium on Industrial Crystallization (ISIC 21), Online.
Li, W, Benyahia, B, Rielly, C (Accepted for publication) 1D and 2-D population balance models applied to mefenamic acid solution crystallisation using gFORMULATE. In 21st International Symposium on Industrial Crystallization (ISIC 21), Online.
Benyahia, B and Liu, J (2021) Systematic model-based dynamic optimization of a combined cooling and antisolvent multistage continuous crystallization process. In
Proceedings of the 31st European Symposium on Computer Aided Process Engineering, Istanbul, Turkey.
Benyahia, B, Anandan, PD, Rielly, C (2021) Control of Batch and Continuous Crystallization Processes using Reinforcement Learning. In
Proceedings of the 31st European Symposium on Computer Aided Process Engineering, Istanbul, Tureky.
Liu, J and
Benyahia, B (2020)
Systematic model-based steady state and dynamic optimization of combined cooling and antisolvent multistage continuous crystallization processes. In
The 2nd International Online Conference on Crystals; Proceedings, Online. DOI:
10.3390/proceedings2020062007.
Benyahia, B, Anandan, PD, Rielly, C (2020)
Optimal trajectory tracking control of batch crystallization process based on reinforcement learning. In
The 2nd International Online Conference on Crystals, Proceedings of The 2nd International Online Conference on Crystals, pp.7731-7731, DOI:
10.3390/iocc_2020-07731.
Benyahia, B and Liu, J (2020)
Steady-state and dynamic optimization of a combined cooling and antisolvent acetylsalicylic acid crystallization process. In
The 2nd International Online Conference on Crystals, Proceedings of The 2nd International Online Conference on Crystals, pp.7236-7236, DOI:
10.3390/iocc_2020-07236.
Bourgade, B, Millar, J,
Benyahia, B, Minton, N, Islam, A (2020)
Implementation of synthetic metabolic pathways in Moorella thermoacetica and Clostridium autoethanogenum. In
CCnet Conference 1, University of Nottingham, Nottingham, UK.
Li, W,
Benyahia, B, Rielly, C (2019)
Shape modification of needle crystals using polymer additives and temperature cycling [Abstract]. In
12th European Congress of Chemical Engineering (ECCE12), Florence, Italy.
Bourgade, B, Millard, J, Benyahia, B, Minton, N, Islam, A (Accepted for publication) Commodity chemicals production from C1 gases in Moorella thermoacetica. In IChemE ChemEngDay UK 2019, Heriot-Watt University, Edinburgh, UK.
Bourgade, B,
Benyahia, B, Minton, N, Islam, A (2019)
Moorella thermoacetica: a chassis organism for biochemicals production?. In
WES Annual Conference 2019: Celebrating the Past, Transforming the Future, London, UK.
Bourgade, B,
Benyahia, B, Minton, N, Islam, MA (2019) Moorella thermoacetica: a chassis organism for biochemicals production. In
WES Annual Conference 2019: Celebrating the Past, Transforming the Future, London, UK.
Bourgade, B,
Benyahia, B, Minton, N, Islam, A (2019)
Commodity chemicals production in Moorella thermoacetica. In
C1net Conference 4, University of Nottingham, Nottingham, UK.
Fayemiwo, KA, Vladisavljevic, GT,
Benyahia, B (2018) Porous amide - based polymer for low pressure CO2 capture. In
UKCCSRC Network Conference, Cambridge.
Mansouri, SS, Udugama, IA, Gernaey, KV,
Benyahia, B (2018)
A shortcut approach for decision-making and operational analysis of an integrated end-to-end continuous pharmaceutical process [Abstract]. In
Process Syetems Engineering, 2018 (PSE 2018), San Diego, USA.
Chiarasumran, N, Blanchard, R,
Benyahia, B (2018)
A comparative life cycle assessment approach of 5 alternative technologies for converting municipal solid waste (MSW) into chemicals and electricity in the UK. In
6th International Congress on Green Process Engineering, Toulouse, France.
Li, W,
Benyahia, B, Rielly, C (2018)
Wet-mill aided continuous cooling mixed suspension mixed product removal crystallizer [Abstract]. In
BACG Conference 2018, University of Limerick, Republic of Ireland.
Sun, Z,
Benyahia, B, Rielly, C (2018)
Control methodologies for robust operation of a nucleator + growth cascade crystallizer: model based steady state and start-up optimization [Abstract]. In
BACG Conference 2018, University of Limerick, Republic of Ireland.
Parekh, R,
Benyahia, B, Rielly, C (2018) A Global State Feedback Linearization and Decoupling MPC of a MIMO Continuous MSMPR Cooling Crystallization Process. In
, Computer Aided Chemical Engineering, pp.1607-1612.
Benyahia, B (2017) Continuous Pharmaceutical Manufacturing: the synergy between QbD and sustainability. In
6th International Conference on Biology, Chemistry and Agronomy, Universidad Autonoma de Guadalajara, Mexico.
Kimuli, EN, Onyemelukwe, I,
Benyahia, B, Rielly, C (2017)
Characterisation of axial dispersion in a meso-scale oscillatory baffled crystalliser using a numerical approach. [Abstract]. In
27th European Symposium on Computer-Aided Process Engineering (ESCAPE-27) / 10th World Congresses of Chemical Engineering, Barcelona, Spain,ISBN: 9780444639653.
Chiarasumran, N, Blanchard, R,
Benyahia, B (2017)
Model reliability and parameter estimability of gasification dynamic models. In
, Barcelona, Spain.
Fysikopoulos, D, Onyemelukwe, I,
Benyahia, B, Nagy, Z, Rielly, C (2017)
Local vs global estimability analysis of population balance models for crystallization processes [Abstract]. In
27th European Symposium on Computer-Aided Process Engineering (ESCAPE-27) / 10th World Congresses of Chemical Engineering, Barcelona, Spain,ISBN: 9780444639707.
Bandulasena, M, Vladisavljevic, GT, Willcock, H,
Benyahia, B (2017)
Production of biocompatible gold nanoparticles for drug delivery using droplet based glass capillary microfluidic [Abstract]. In
ChemEngDayUK 2017, Birmingham, UK.
Bandulasena, M, Vladisavljevic, G, Willcock, H,
Benyahia, B (2017)
Mixing in microfluidic devices as a new strategy for fabrication of nanoparticles. In
IChemE Fluid Mixing Processes Special Interest Group, Research Student Event, Loughborough, UK.
Bandulasena, M, Vladisavljevic, G, Willcock, H,
Benyahia, B (2017)
Production of biocompatible gold nanoparticles using glass capillary microfluidic devices for drug delivery applications [Powerpoint Presentation]. In
Fluid Mechanics of Nanostructructured Materials, 1st SIG Meeting, 14 September 2017, Queen Mary University of London.
Chiarasumran, N, Blanchard, R,
Benyahia, B (2017)
Towards more accurate and reliable mathematical model for steam gasification [Abstract]. In
.
Parekh, R,
Benyahia, B, Rielly, C (2017)
Input-output state feedback linearization and model predictive control of an MSMPR crystalliser [Abstract]. In
20th International Symposium on Industrial Crystallization (ISIC 20), Dublin, Ireland.
Parekh, R,
Benyahia, B, Rielly, C (2017)
State feedback linearization and adaptive model predictive control applied to a simulated MSMPR crystalliser [Abstract]. In
British Association For Crystal Growth Annual Conference 2017 (BACG 2017), Manchester.
Bandulasena, M, Vladisavljevic, G,
Benyahia, B (2016)
Continuous synthesis of bio-compatible gold nanoparticles using glass capillary microfluidic devices [conference poster]. In
“Functional Nanomaterials in Industrial Applications: Academic – Industry Meet”, Preston, UK, pp.53-53.
Fayemiwo, K, Nabavi, A, Vladisavljevic, G,
Benyahia, B (2016)
Amide-based imprinted polymers as potential adsorbents for CO2 capture [Abstract]. In
2nd Annual InterPore UK Chapter Conference, Particle Characterisation Interest Group, Royal Society of Chemistry, Loughborough, pp.11-11.
Fayemiwo, K, Nabavi, A, Vladisavljevic, G,
Benyahia, B (2016)
Synthesis and characterization of porous polymer-based adsorbents for CO2 capture [Abstract]. In
2nd Annual InterPore UK Chapter Conference, Particle Characterisation Interest Group, Loughborough, pp.37-37.
Fysikopoulos, D, Su, Q, Trybala, A,
Benyahia, B, Nagy, Z, Rielly, C (2016)
Population balance modelling of continuous crystallization processes [Abstract]. In
4th Quality by Design Symposium, De Monfort University.
Fysikopoulos, D, Borsos, A,
Benyahia, B, Rielly, C, Nagy, Z (2016)
Parameter identification, reliability and model discrimination of population balance models for crystallization [Poster]. In
12th International Workshop of the Crystal Growth of Organic Material and 47th Annual British Association of Crystal Growth Conference Joint Conference, University of Leeds.
Kimuli, EN, Onyemelukwe, I,
Benyahia, B, Rielly, C (2016)
Determination of residence time distribution and axial dispersion coefficient in a meso-scale oscillatory baffled crystallizer using a computational fluid dynamics approach [Abstract]. In
CGOM12/BACG2016, University of Leeds.
Fysikopoulos, D, Borsos, A,
Benyahia, B, Nagy, Z, Rielly, C (2016)
Model reliability of multi-dimensional population balance models for crystallization [abstract]. In
PSE@ResearchDayUK, Imperial College, London.
Hreiz, R, Roche, N,
Benyahia, B, Latifi, A (2015) Multi-objective optimization of large-size waste water treatment
plants operation and design. In
10th European Congress of Chemical Engineering (ECCE 10), Nice, France.
Hreiz, R, Roche, N,
Benyahia, B, Latifi, A (2015) Multi-objective optimization of small-size wastewater treatment
plants operation. In
PSE2015/ESCAPE25, Copenhagen, Denmark.
Benyahia, B, Latifi, A, Fonteix, C, Pla, F (2015) Optimized production of multilayered monodisperse polymer
nanoparticles. In
PSE2015/ESCAPE25, Copenhagen, Denmark.
Bandulasena, M, Vladisavljevic, G,
Benyahia, B (2015)
Towards a novel microfluidic device for synthesis of gold nanoparticles for drug delivery. In
“Inspiring Research”, Loughborough University Annual Research Conference 2015, Sir Denis Rooke Building, Holywell Park, Loughborough.
Zhou, L, Su, M,
Benyahia, B, Singh, A, Barton, PI, Trout, BL, Myerson, AS, Braatz, RD (2014) Mathematical modeling and design of layer crystallization in a concentric annulus with and without recirculation. In
, Process Development Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future, pp.113-115.
Lakerveld, R,
Benyahia, B, Hieder, PL, Zhang, H, Wolfe, A, Testa, CJ, Ogden, S, Hersey, DR, Mascia, S, Evans, JMB, Braatz, RD, Barton, PI (2014) The application of an automated plant-wide control strategy for a
continuous pharmaceutical pilot plant. In
American Control Conference, Portland, Oregon, USA, pp.3512-3517.
Lakerveld, R,
Benyahia, B, Heider, PL, Zhang, H, Mascia, S, Evans, JMB, Braatz, RD, Barton, PI (2013) A plant-wide control strategy for an integrated continuous pharmaceutical pilot plant. In
Pharma IQ’s 10th Annual PAT and Quality by Design Conference, London, UK.
Paulen, R,
Benyahia, B, Latifi, MA, Fikar, M (2013)
Optimal feeding of emulsion polymerization reactor for styrene and butyl acrylate copolymerization. In
19th International Conference on Process Control (PC 13), High Tatras, Slovakia, pp.427-432, ISBN: 978-1-4799-0926-1. DOI:
10.1109/PC.2013.6581448.
Paulen, R,
Benyahia, B, Latifi, MA, Fikar, M (2013)
Dynamic optimization of semi-batch emulsion copolymerization reaction of styrene/butyl acrylate in the presence of a chain transfer agent. In Kraslawski, A and Turunen, I (ed)
European Symposium on Computer Aided Process Engineering (ESCAPE 23), Computer Aided Chemical Engineering, Lappeenranta, Finland, pp.721-726, DOI:
10.1016/B978-0-444-63234-0.50121-4.
Lakerveld, R,
Benyahia, B, Heider, PL, Zhang, H, Wolf, A, Tesla, C, Ogden, S, Hersey, DR, Mascia, S, Evans, JMB, Braatz, DR, Barton, PI (2013) Plant-wide control of an integrated continuous pharmaceutical pilot plant. In
9th European Congress of Chemical Engineering (ECCE9) and 2nd European Congress of Applied Biotechnology (ECAB2), The Hague, Netherlands.
Zhou, L, Su, M,
Benyahia, B, Singh, A, Barton, PI, Trout, BL, Myerson, AS, Braatz, RD (2013)
Mathematical Modeling and Design of Layer Crystallization in a Concentric Annulus With and Without Recirculation. In
AIChE Annual Meeting, San Francisco, -.
Zhou, L, Su, M,
Benyahia, B, Singh, A, Barton, PI, Trout, BL, Myerson, AS, Braatz, RD (2013) Mathematical modeling and design of layer crystallization in a concentric annulus with and without recirculation. In
, Separations Division 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future, pp.143-145.
Zhou, L, Su, M,
Benyahia, B, Singh, A, Barton, PI, Trout, BL, Myerson, AS, Braatz, RD (2013) Mathematical modeling and design of layer crystallization in a concentric annulus with and without recirculation. In
, Particle Technology Forum 2013 - Core Programming Area at the 2013 AIChE Annual Meeting: Global Challenges for Engineering a Sustainable Future, pp.115-117.
Paulen, R,
Benyahia, B, Latifi, MA, Fikar, M (2012)
Dynamic simulation of hybrid differential algebraic systems using gPROMS: case study in emulsion polymerization. In Taufer, I, Honc, D, Javurek, M (ed)
10th International Conference on Process Control 2012, Kouty nad Desnou, Czech Republic, pp.C013a1-C013a14.
Lakerveld, R,
Benyahia, B, Heider, PL, Zhang, H, Mascia, S, Evans, JMB, Braatz, DR, Barton, PI (2012) The application of a plant-wide control strategy for a continuous pharmaceutical process at the Novartis-MIT center for continuous manufacturing. In
International QbD/PAT Conference, Heidelberg, Germany.
Lakerveld, R, Evans, JMB,
Benyahia, B, Braatz, DR, Barton, PI (2012) Implementing continuous manufacturing: the synergy between plant-wide control, modeling, and QbD. In
International Pharma QbD forum, Berlin, Germany.
Benyahia, B, Lakerveld, R, Barton, PI (2011)
A plant-wide dynamic model of a continuous pharmaceutical process. In
AIChE Annual Meeting, Minneapolis, USA, No 506b.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F (2010)
Control of the morphology of nanoparticles resulting from the dynamic optimization of a fed-batch emulsion copolymerization process. In
TechConnect world Nanotech Conference and Expo 2010, Anaheim, California, USA, pp.930-933.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F (2010)
Estimability analysis and parameter identification for a batch emulsion copolymerization reactor in the presence of a chain transfer agent. In
21st International Symposia on Chemical Reaction Engineering (ISCRE 21), Philadelphia, USA.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F, Nacef, S (2009)
Multiobjective dynamic optimization of a fed-batch copolymerization reactor. In
French Society of Operational Research and Decision Support ROADEF 09, Nancy, France, pp.189-191.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F (2009)
Multiobjective optimization of an emulsion copolymerization process. In Fikar, M and Kvasnica, M (ed)
17th International Conference on Process Control (PC09), Štrbské Pleso, High Tatras, Slovakia, pp.80-85.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F (2009)
Modeling and optimization of fed-batch emulsion copolymerization of styrene and butyl acrylate in the presence of a chain transfer agent. In
12th Congress of the French Society of Process Engineering 2009 (SFGP 2009), Récents Progrès en Génie des Procédés, Marseille, France, pp.No 773-Axx1-Axx6, ISBN: 2-910239-72-1.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F (2009)
Modeling and optimization of fed-batch emulsion copolymerization of styrene and butyl acrylate in the presence of a chain transfer agent. In
8th World Congress of Chemical Engineering (WCCE 8), Montreal, Canada, No 02245.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F, Nacef, S (2008)
Elaboration of a tendency model and determination of optimal feed rate profiles for styrene/butyl acrylate semi-batch emulsion copolymerization reactor. In
CHISA 2008 (18th International Congress of Chemical Engineering and Process Engineering), Prague, Czech Republic, Paper No 1776 p7.92.
Benyahia, B, Latifi, MA, Fonteix, C, Pla, F (2007) Modeling and optimization of a batch emulsion copolymerization reactor. In
11th Congress of the French Society of Process Engineering 2007 (SFGP 2007), Saint-Etienne, France, No 122.
Benyahia, B, Latifi, MA, Schrawen, C, Fonteix, C, Pla, F (2007) Etude de la copolymérisation en émulsion dans un réacteur batch du styrène et de l’acrylate de butyle. In
Seminar of the Doctoral School RP2E "Ingénierie des Ressources, Procédés, Produits et Environnement ", Nancy, France, ISBN: 2-9518564-5-8.
Benyahia, B and Cherif, K (2004) Etude de l’effet des eaux usées industrielles sur les paramètres physico-chimiques des eaux de forages de la ville de M’sila. In
International Seminar on Urban Environmental Ecology: current status and perspectives, Constantine, Algeria.
Benyahia, B (2004)
Mathematical modeling of a continuous solution polymerization reactor: case-study MMA polymerization. In
2nd International Symposium on Hydrocarbons and Chemistry (2nd ISHC), Ghardaia, Algeria, pp.180-181.
Benyahia, B and Chafâa, K (2004) Fuzzy control of a continuous MMA polymerization reactor. In
First Congress on Electronics (PCE’04), BBA, Algeria.
Benyahia, B, Cherif, K, Belouadah, H, Khermouche, S (2004) Physico-chemical analyzes of the drinking water in M’sila: case study Hodna’s basin wells. In
First National Congress on Chemistry, M'sila, Algeria, p.83.
Benyahia, B (2004) Synthesis and characterization of a new geomembrane stabilized by DOP, DIDP, and DINP. In
Second National Seminar on Chemistry, Tebessa, Algeria, p.195.
Benyahia, B, Djegbalou, D, Bakour, A (2004) Modeling and dynamic simulation of a fed-batch penicillin bioreactor. In
National Days of Chemistry, Oran, Algeria.
Benyahia, B and Nacef, S (2003) Control of a solution copolymerization continuous stirred tank reactor (CSTR). In
Science Conference, Seiyun, Yemen, p.72.
Benyahia, B, Benchadi, N, Lamara, NE (2003) Characterization of a new geomembrane stabilized by DOP, DIDP and DINP. In
First International Conference on Materials Science and Engineering (ICMSE-1), M'sila, Algeria, pp.87-88.
Benyahia, B, Nacef, S, Krim, F (2002) Control of a solution copolymerization continuous stirred tank reactor (CSTR): robustness and change of the set-points. In
SAC 2002 (Algerian Chemical Society), Setif, Algeria, CO 5-15.
Benyahia, B and Nacef, S (2002) Modeling and validation of a CSTR copolymerization reactor. In
First National Seminar on Chemistry, Tebessa, Algeria, pp.5-6.
Benyahia, B and Boudjemâa, B (2002) Synthesis and characterization of a commercial PVC sealing sheet. In
First National Seminar on Chemistry, Tebessa, Algeria, pp.73-74.
Benyahia, B, Nacef, S, Krim, F (2001) Nonlinear control of a solution copolymerization reactor: controllers tuning. In
3rd Algerian Congress of Process Engineering, Ouargla, Algeria, p.9.
Benyahia, B, Nacef, S, Krim, F (2000) Etude en simulation de la commande non-linéaire d’un réacteur continu parfaitement agité de copolymérisation en solution: modélisation et linéarisation par retour d’état. In
First International Symposium on Hydrocarbons and Chemistry, Boumerdes, Algeria.
Benyahia, B, Nacef, S, Krim, F (2000)
Nonlinear model-based control of a solution copolymerization continuous stirred
tank reactor. In
First Instrumentation and Measurement in Petroleum Applications Conference (IMPAC 2000), Boumerdes, Algeria, pp.192-197.
Benyahia, B and Nacef, S (1999) Etude et simulation de la commande d’un RCPA de copolymérisation en solution. In
2nd National Seminar on Process Engineering, USTHB, ALgiers, p.28.
