Journal Articles
Pearce, A, Parkinson, SJ, Akar, I, Derry, MJ, Topham, PD, Mathers, RT, Stavros, VG, O’Reilly, RK (2023)
Mechanistic insights into polymerization-induced self-assembly using maleimide-based fluorophores,
Macromolecules, 56(23), pp.9443-9454, ISSN: 0024-9297. DOI:
10.1021/acs.macromol.3c01451.
Akar, I,
Pearce, AK, Kumar, CMS, Ferguson, C, O'Reilly, RK (2023)
Preparation of functional nanoparticles of mPEG‐b‐P(DMA‐co‐HA) copolymers via polymerization‐induced thermal self‐assembly,
Journal of Polymer Science, 61(22), pp.2932-2944, ISSN: 2642-4150. DOI:
10.1002/pol.20230420.
Li, Z,
Pearce, AK, Du, J, Dove, AP, O'Reilly, RK (2023)
Uniform antibacterial cylindrical nanoparticles for enhancing the strength of nanocomposite hydrogels,
Journal of Polymer Science, 61(1), pp.44-55, ISSN: 2642-4150. DOI:
10.1002/pol.20210853.
Sikder, A,
Pearce, AK, Kumar, CMS, O’Reilly, RK (2023)
Correction: Elucidating the role of multivalency, shape, size and functional group density on antibacterial activity of diversified supramolecular nanostructures enabled by templated assembly,
Materials Horizons, 10(7), pp.2706-2706, ISSN: 2051-6347. DOI:
10.1039/d3mh90020g.
Moloney, C, Mehradnia, F, Cavanagh, RJ, Ibrahim, A,
Pearce, AK, Ritchie, AA, Clarke, P, Rahman, R, Grabowska, AM, Alexander, C (2023)
Chain-extension in hyperbranched polymers alters tissue distribution and cytotoxicity profiles in orthotopic models of triple negative breast cancers,
Biomaterials Science, 11(19), pp.6545-6560, ISSN: 2047-4830. DOI:
10.1039/d3bm00609c.
Sikder, A,
Pearce, A, Kumar, CMS, O’Reilly, RK (2022)
Elucidating the role of multivalency, shape, size and functional group density on antibacterial activity of diversified supramolecular nanostructures enabled by templated assembly,
Materials Horizons, 10(1), pp.171-178, ISSN: 2051-6347. DOI:
10.1039/d2mh01117d.
Pervez, M,
Pearce, AK, Husband, JT, Male, L, Torrent‐Sucarrat, M, O'Reilly, RK (2022)
Enhancing Dual‐State Emission in Maleimide Fluorophores through Fluorocarbon Functionalisation,
Chemistry – A European Journal, 28(58), ISSN: 0947-6539. DOI:
10.1002/chem.202201877.
Akar, I, Foster, JC, Leng, X,
Pearce, AK, Mathers, RT, O’Reilly, RK (2022)
Log Poct/SA Predicts the Thermoresponsive Behavior of P(DMA-co-RA) Statistical Copolymers,
ACS Macro Letters, 11(4), pp.498-503, ISSN: 2161-1653. DOI:
10.1021/acsmacrolett.1c00776.
Anane-Adjei, AB, Fletcher, NL, Cavanagh, RJ, Houston, ZH, Crawford, T,
Pearce, AK, Taresco, V, Ritchie, AA, Clarke, P, Grabowska, AM, Gellert, PR, Ashford, MB, Kellam, B, Thurecht, KJ, Alexander, C (2022)
Synthesis, characterisation and evaluation of hyperbranched N-(2-hydroxypropyl) methacrylamides for transport and delivery in pancreatic cell lines in vitro and in vivo,
Biomaterials Science, 10(9), pp.2328-2344, ISSN: 2047-4830. DOI:
10.1039/d1bm01548f.
Pearce, AK and O’Reilly, RK (2021)
Polymers for Biomedical Applications: The Importance of Hydrophobicity in Directing Biological Interactions and Application Efficacy,
Biomacromolecules, 22(11), pp.4459-4469, ISSN: 1525-7797. DOI:
10.1021/acs.biomac.1c00434.
Li, Z,
Pearce, AK, Dove, AP, O’Reilly, RK (2021)
Precise Tuning of Polymeric Fiber Dimensions to Enhance the Mechanical Properties of Alginate Hydrogel Matrices,
Polymers, 13(13), pp.2202-2202, DOI:
10.3390/polym13132202.
Jacob, PL, Ruiz Cantu, LA,
Pearce, AK, He, Y, Lentz, JC, Moore, JC, Machado, F, Rivers, G, Apebende, E, Fernandez, MR, Francolini, I, Wildman, R, Howdle, SM, Taresco, V (2021)
Poly (glycerol adipate) (PGA) backbone modifications with a library of functional diols: Chemical and physical effects,
Polymer, 228, pp.123912-123912, ISSN: 0032-3861. DOI:
10.1016/j.polymer.2021.123912.
Sikder, A,
Pearce, AK, Parkinson, SJ, Napier, R, O’Reilly, RK (2021)
Recent Trends in Advanced Polymer Materials in Agriculture Related Applications,
ACS Applied Polymer Materials, 3(3), pp.1203-1217, ISSN: 2637-6105. DOI:
10.1021/acsapm.0c00982.
Miller, AJ,
Pearce, AK, Foster, JC, O’Reilly, RK (2021)
Probing and Tuning the Permeability of Polymersomes,
ACS Central Science, 7(1), pp.30-38, ISSN: 2374-7943. DOI:
10.1021/acscentsci.0c01196.
Taresco, V, Abelha, TF, Cavanagh, RJ, Vasey, CE, Anane‐Adjei, AB,
Pearce, AK, Monteiro, PF, Spriggs, KA, Clarke, P, Ritchie, A, Martin, S, Rahman, R, Grabowska, AM, Ashford, MB, Alexander, C (2021)
Functionalized Block Co‐Polymer Pro‐Drug Nanoparticles with Anti‐Cancer Efficacy in 3D Spheroids and in an Orthotopic Triple Negative Breast Cancer Model,
Advanced Therapeutics, 4(1), ISSN: 2366-3987. DOI:
10.1002/adtp.202000103.
Lawrenson, SB,
Pearce, AK, Hart, S, Whitwood, AC, O’Reilly, RK, North, M (2021)
Synthesis of cytotoxic spirocyclic imides from a biomass-derived oxanorbornene,
Tetrahedron, 77, pp.131754-131754, ISSN: 0040-4020. DOI:
10.1016/j.tet.2020.131754.
Vdovchenko, A,
Pearce, AK, Freeley, M, O'Reilly, RK, Resmini, M (2021)
Effect of heterogeneous and homogeneous polymerisation on the structure of pNIPAm nanogels,
Polymer Chemistry, 12(47), pp.6854-6864, ISSN: 1759-9954. DOI:
10.1039/d1py01333e.
Pearce, AK, Wilks, TR, Arno, MC, O’Reilly, RK (2020)
Synthesis and applications of anisotropic nanoparticles with precisely defined dimensions,
Nature Reviews Chemistry, 5(1), pp.21-45, DOI:
10.1038/s41570-020-00232-7.
Foster, JC, Akar, I, Grocott, MC,
Pearce, AK, Mathers, RT, O’Reilly, RK (2020)
100th Anniversary of Macromolecular Science Viewpoint: The Role of Hydrophobicity in Polymer Phenomena,
ACS Macro Letters, 9(11), pp.1700-1707, ISSN: 2161-1653. DOI:
10.1021/acsmacrolett.0c00645.
Pearce, AK, Anane‐Adjei, AB, Cavanagh, RJ, Monteiro, PF, Bennett, TM, Taresco, V, Clarke, PA, Ritchie, AA, Alexander, MR, Grabowska, AM, Alexander, C (2020)
Effects of Polymer 3D Architecture, Size, and Chemistry on Biological Transport and Drug Delivery In Vitro and in Orthotopic Triple Negative Breast Cancer Models,
Advanced Healthcare Materials, 9(22), ISSN: 2192-2640. DOI:
10.1002/adhm.202000892.
Rauschenbach, M, Lawrenson, SB, Taresco, V,
Pearce, AK, O'Reilly, RK (2020)
Antimicrobial Hyperbranched Polymer–Usnic Acid Complexes through a Combined ROP‐RAFT Strategy,
Macromolecular Rapid Communications, 41(18), ISSN: 1022-1336. DOI:
10.1002/marc.202000190.
Phan, H, Kortsen, K, Englezou, G, Couturaud, B, Nedoma, AJ,
Pearce, AK, Taresco, V (2020)
Functional initiators for the ring‐opening polymerization of polyesters and polycarbonates: An overview,
Journal of Polymer Science, 58(14), pp.1911-1923, ISSN: 2642-4150. DOI:
10.1002/pol.20200313.
Monteiro, PF, Gulfam, M, Monteiro, CJ, Travanut, A, Abelha, TF,
Pearce, AK, Jerôme, C, Grabowska, AM, Clarke, PA, Collins, HM, Heery, DM, Gershkovich, P, Alexander, C (2020)
Synthesis of micellar-like terpolymer nanoparticles with reductively-cleavable cross-links and evaluation of efficacy in 2D and 3D models of triple negative breast cancer,
Journal of Controlled Release, 323, pp.549-564, ISSN: 0168-3659. DOI:
10.1016/j.jconrel.2020.04.049.
Greco, C, Taresco, V,
Pearce, AK, Vasey, CE, Smith, S, Rahman, R, Alexander, C, Cavanagh, RJ, Musumeci, F, Schenone, S (2020)
Development of Pyrazolo[3,4-d]pyrimidine Kinase Inhibitors as Potential Clinical Candidates for Glioblastoma Multiforme,
ACS Medicinal Chemistry Letters, 11(5), pp.657-663, ISSN: 1948-5875. DOI:
10.1021/acsmedchemlett.9b00530.
Gordhan, D, Swainson, SME,
Pearce, AK, Styliari, ID, Lovato, T, Burley, JC, Garnett, MC, Taresco, V (2020)
Poly (Glycerol Adipate): From a Functionalized Nanocarrier to a Polymeric-Prodrug Matrix to Create Amorphous Solid Dispersions,
Journal of Pharmaceutical Sciences, 109(3), pp.1347-1355, ISSN: 0022-3549. DOI:
10.1016/j.xphs.2019.12.004.
Vestri, A,
Pearce, AK, Cavanagh, R, Styliari, ID, Sanders, C, Couturaud, B, Schenone, S, Taresco, V, Jakobsen, RR, Howdle, SM, Musumeci, F, Sagnelli, D (2020)
Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device,
Coatings, 10(2), pp.125-125, DOI:
10.3390/coatings10020125.
Sodano, F, Cavanagh, RJ,
Pearce, AK, Lazzarato, L, Rolando, B, Fraix, A, Abelha, TF, Vasey, CE, Alexander, C, Taresco, V, Sortino, S (2020)
Enhancing doxorubicin anticancer activity with a novel polymeric platform photoreleasing nitric oxide,
Biomaterials Science, 8(5), pp.1329-1344, ISSN: 2047-4830. DOI:
10.1039/c9bm01644a.
Pearce, AK, Vasey, CE, Anane‐Adjei, AB, Sodano, F, Crucitti, VC, Irvine, DJ, Howdle, SM, Alexander, C, Taresco, V (2019)
Versatile, Highly Controlled Synthesis of Hybrid (Meth)acrylate–Polyester–Carbonates and their Exploitation in Tandem Post‐Polymerization–Functionalization,
Macromolecular Chemistry and Physics, 220(21), ISSN: 1022-1352. DOI:
10.1002/macp.201900270.
Pearce, AK and O’Reilly, RK (2019)
Insights into Active Targeting of Nanoparticles in Drug Delivery: Advances in Clinical Studies and Design Considerations for Cancer Nanomedicine,
Bioconjugate Chemistry, 30(9), pp.2300-2311, ISSN: 1043-1802. DOI:
10.1021/acs.bioconjchem.9b00456.
Phan, H, Minut, RI, McCrorie, P, Vasey, C, Larder, RR, Krumins, E, Marlow, M, Rahman, R, Alexander, C, Taresco, V,
Pearce, AK (2019)
Role of self‐assembly conditions and amphiphilic balance on nanoparticle formation of PEG‐PDLLA copolymers in aqueous environments,
Journal of Polymer Science Part A: Polymer Chemistry, 57(17), pp.1801-1810, ISSN: 0887-624X. DOI:
10.1002/pola.29451.
Swainson, SME, Taresco, V,
Pearce, AK, Clapp, LH, Ager, B, McAllister, M, Bosquillon, C, Garnett, MC (2019)
Exploring the enzymatic degradation of poly(glycerol adipate),
European Journal of Pharmaceutics and Biopharmaceutics, 142, pp.377-386, ISSN: 0939-6411. DOI:
10.1016/j.ejpb.2019.07.015.
Pearce, AK, Foster, JC, O'Reilly, RK (2019)
Recent developments in entropy‐driven ring‐opening metathesis polymerization: Mechanistic considerations, unique functionality, and sequence control,
Journal of Polymer Science Part A: Polymer Chemistry, 57(15), pp.1621-1634, ISSN: 0887-624X. DOI:
10.1002/pola.29428.
Vasey, CE,
Pearce, AK, Sodano, F, Cavanagh, R, Abelha, T, Cuzzucoli Crucitti, V, Anane-Adjei, AB, Ashford, M, Gellert, P, Taresco, V, Alexander, C (2019)
Amphiphilic tri- and tetra-block co-polymers combining versatile functionality with facile assembly into cytocompatible nanoparticles,
Biomaterials Science, 7(9), pp.3832-3845, ISSN: 2047-4830. DOI:
10.1039/c9bm00667b.
Ruiz‐Cantu, LA,
Pearce, AK, Burroughs, L, Bennett, TM, Vasey, CE, Wildman, R, Irvine, DJ, Alexander, C, Taresco, V (2019)
Synthesis of Methacrylate‐Terminated Block Copolymers with Reduced Transesterification by Controlled Ring‐Opening Polymerization,
Macromolecular Chemistry and Physics, 220(2), ISSN: 1022-1352. DOI:
10.1002/macp.201800459.
Bennett, TM, He, G, Larder, RR, Fischer, MG, Rance, GA, Fay, MW,
Pearce, AK, Parmenter, CDJ, Steiner, U, Howdle, SM (2018)
Clean Block Copolymer Microparticles from Supercritical CO2: Universal Templates for the Facile and Scalable Fabrication of Hierarchical Mesostructured Metal Oxides,
Nano Letters, 18(12), pp.7560-7569, ISSN: 1530-6984. DOI:
10.1021/acs.nanolett.8b03044.
Pearce, AK, Blok, AJ, Yilmaz, G, Singh, N, Cavanagh, RJ, Abelha, T, Taresco, V, Alexander, C (2018) Functional polymers for drug delivery: Prospects and challenges,
Chimica Oggi/Chemistry Today, 36(6), pp.38-42, ISSN: 0392-839X.
Pearce, AK, Blok, AJ, Yilmaz, G, Singh, N, Cavanagh, RJ, Abelha, T, Taresco, V, Alexander, C (2018)
Functional polymers for drug delivery prospects and challenges,
CHIMICA OGGI-CHEMISTRY TODAY, 36(5), pp.38-42, ISSN: 0392-839X.
Taresco, V, Alexander, C, Singh, N,
Pearce, AK (2018)
Stimuli‐Responsive Prodrug Chemistries for Drug Delivery,
Advanced Therapeutics, 1(4), ISSN: 2366-3987. DOI:
10.1002/adtp.201800030.
Styliari, ID, Conte, C,
Pearce, AK, Hüsler, A, Cavanagh, RJ, Limo, MJ, Gordhan, D, Nieto‐Orellana, A, Suksiriworapong, J, Couturaud, B, Williams, P, Hook, AL, Alexander, MR, Garnett, MC, Alexander, C, Burley, JC, Taresco, V (2018)
High‐Throughput Miniaturized Screening of Nanoparticle Formation via Inkjet Printing,
Macromolecular Materials and Engineering, 303(8), ISSN: 1438-7492. DOI:
10.1002/mame.201800146.
Pearce, AK, Simpson, JD, Fletcher, NL, Houston, ZH, Fuchs, AV, Russell, PJ, Whittaker, AK, Thurecht, KJ (2017)
Localised delivery of doxorubicin to prostate cancer cells through a PSMA-targeted hyperbranched polymer theranostic,
Biomaterials, 141, pp.330-339, ISSN: 0142-9612. DOI:
10.1016/j.biomaterials.2017.07.004.
Pearce, AK, Travanut, A, Couturaud, B, Taresco, V, Howdle, SM, Alexander, MR, Alexander, C (2017)
Versatile Routes to Functional RAFT Chain Transfer Agents through the Passerini Multicomponent Reaction,
ACS Macro Letters, 6(7), pp.781-785, ISSN: 2161-1653. DOI:
10.1021/acsmacrolett.7b00415.
Pearce, AK, Fuchs, AV, Fletcher, NL, Thurecht, KJ (2016)
Targeting Nanomedicines to Prostate Cancer: Evaluation of Specificity of Ligands to Two Different Receptors In Vivo,
Pharmaceutical Research, 33(10), pp.2388-2399, ISSN: 0724-8741. DOI:
10.1007/s11095-016-1945-x.
Fuchs, AV, Tse, BWC,
Pearce, AK, Yeh, M-C, Fletcher, NL, Huang, SS, Heston, WD, Whittaker, AK, Russell, PJ, Thurecht, KJ (2015)
Evaluation of Polymeric Nanomedicines Targeted to PSMA: Effect of Ligand on Targeting Efficiency,
Biomacromolecules, 16(10), pp.3235-3247, ISSN: 1525-7797. DOI:
10.1021/acs.biomac.5b00913.
Pearce, AK, Rolfe, BE, Russell, PJ, Tse, BW-C, Whittaker, AK, Fuchs, AV, Thurecht, KJ (2014)
Development of a polymer theranostic for prostate cancer,
Polym. Chem, 5(24), pp.6932-6942, ISSN: 1759-9954. DOI:
10.1039/c4py00999a.
